{"id":"W3114965763","doi":"10.1371/journal.pone.0244366","title":"Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Dendritic cell; Immune system; Cell biology; Biology; CD8; T cell; Inflammation; Acquired immune system; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396542,0.0001397388,0.0002817865,0.0001028598,0.00006661411,0.0002397492,0.0001267965,0.0002009168,0.001229529],"category_scores_gemma":[0.0001739592,0.00007466252,0.000133274,0.00007513585,0.0001510676,0.0001452912,0.0001817961,0.0004608241,0.0003713835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996145,"about_ca_system_score_gemma":0.0001962569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001865932,"about_ca_topic_score_gemma":0.0002156815,"domain_scores_codex":[0.9998161,0.0000423381,0.00001453522,0.00003395647,0.00003854405,0.00005452161],"domain_scores_gemma":[0.9998726,0.00003493492,0.00002359416,0.00001637498,0.00001571054,0.00003672384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002179039,0.00004208717,0.000158113,0.00003248299,0.000002362997,0.00002606509,0.0000102272,0.00008415015,0.9966525,0.0001340132,0.00007941952,0.002560654],"study_design_scores_gemma":[0.00004531073,0.0007512239,0.00251392,0.000009731717,0.00001181067,0.0002003448,0.00002628268,0.001482753,0.9872662,0.0001167765,0.007573098,0.000002462279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867105,0.003815356,0.003895498,0.0003047815,0.00009831503,0.00006581683,0.0002500157,0.00009815025,0.004761637],"genre_scores_gemma":[0.9956837,0.0008278578,0.001208068,0.0001043866,0.00003695557,0.00004169948,0.0001800321,0.00001210342,0.001905308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001229529,"threshold_uncertainty_score":0.004113197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05004012422241524,"score_gpt":0.238281917658852,"score_spread":0.1882417934364368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}