{"id":"W3115444894","doi":"10.1371/journal.pgen.1009190","title":"Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Manitoba; University of Toronto; SickKids Foundation; Toronto Centre for Phenogenomics; Hospital for Sick Children","funders":"National Cancer Institute; National Eye Institute; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences; Medical Research Council; PHENOMIN; Akademie Věd České Republiky; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Ministerstvo Školství, Mládeže a Tělovýchovy; CHIST-ERA; National Human Genome Research Institute; Wellcome Trust; Agence Nationale de la Recherche; European Regional Development Fund; European Commission; Univerzita Karlova v Praze; INFRAFRONTIER; European Bioinformatics Institute; National Institutes of Health; Ontario Genomics; Genome Canada; Wellcome","keywords":"Bone mineral; Biology; Osteoporosis; Gene; In silico; Bone remodeling; Bone density; Mutant; Candidate gene; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003319115,0.0004346444,0.0003865167,0.001391695,0.0001999057,0.0003663672,0.000293214,0.0004159477,0.001570058],"category_scores_gemma":[0.0004235168,0.0001965665,0.0004400264,0.0006492034,0.0002796473,0.0001127503,0.0002852769,0.0004677465,0.0003328929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425544,"about_ca_system_score_gemma":0.0001830013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007206605,"about_ca_topic_score_gemma":0.001327495,"domain_scores_codex":[0.9996597,0.00004117465,0.00004288,0.0001129079,0.00009622318,0.00004715972],"domain_scores_gemma":[0.9996114,0.0001562299,0.000112475,0.00004888778,0.00002368915,0.00004730889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000307391,0.00002617732,0.009147733,0.00005000021,0.00004655921,0.0004988433,0.00003836886,0.0004341195,0.9836135,0.000261081,0.00009278816,0.005483343],"study_design_scores_gemma":[0.00008838529,0.0004496085,0.4750225,0.00007532912,0.0003562437,0.008209921,0.0002087353,0.007953539,0.4960449,0.001799494,0.009712555,0.00007873875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820925,0.0006724568,0.0127046,0.00007307971,0.00001156913,0.00002101068,0.003363899,0.000185207,0.0008756934],"genre_scores_gemma":[0.9813612,0.0008335254,0.01233309,0.0001377966,0.000008192406,0.00006950017,0.00379708,0.0001667674,0.001292823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570058,"threshold_uncertainty_score":0.005252302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086651390938023,"score_gpt":0.2209604472281774,"score_spread":0.2000939333187972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}