{"id":"W3115449577","doi":"10.3390/biom11010032","title":"RNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions","year":2020,"lang":"en","type":"review","venue":"Biomolecules","topic":"Diffusion and Search Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Hokkaido University","keywords":"Transcription (linguistics); Reaction rate; Chemical reaction; DNA; Rate equation; Ratchet; Biophysics; Computational biology; Chemistry; Biology; Physics; Statistical physics; Genetics; Thermodynamics; Kinetics; Classical mechanics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008989961,0.0002226194,0.0006336312,0.00003701374,0.00002921412,0.000007429789,0.0002050278,0.0001877358,0.000002647931],"category_scores_gemma":[0.00009751794,0.0001462748,0.0003353041,0.0001077372,0.000423302,0.000001957338,0.0001430432,0.0001181282,8.412353e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001190774,"about_ca_system_score_gemma":0.00009070303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001059476,"about_ca_topic_score_gemma":0.000002413678,"domain_scores_codex":[0.9989538,0.00008587892,0.0003862743,0.0002882599,0.0001530639,0.0001327103],"domain_scores_gemma":[0.9993662,0.00003138493,0.0002095586,0.0002602446,0.00006850573,0.00006416809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000186802,0.00006058091,3.59246e-8,0.002306225,0.0002636374,0.000001329633,0.00004168618,1.721591e-8,0.8055577,0.001670782,0.000158821,0.1899206],"study_design_scores_gemma":[0.0003442175,0.0002730489,2.912644e-7,0.001724825,0.0006995741,0.0000334267,0.000327753,0.00002772044,0.5334848,0.0004476528,0.4623088,0.0003278899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001359956,0.9971774,0.0007648331,0.0001221925,0.00005717587,0.0002831444,0.0001622012,0.000006268803,0.00006687102],"genre_scores_gemma":[0.006584042,0.9925755,0.0004309552,0.00003565703,0.00006518303,0.00003424006,0.0002050867,0.00002565808,0.00004372002],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4621499,"threshold_uncertainty_score":0.5964914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04448606256882922,"score_gpt":0.3417055062851057,"score_spread":0.2972194437162765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}