{"id":"W3115521415","doi":"10.1101/2020.12.20.423672","title":"The CP110-CEP97-CEP290 module orchestrates a centriolar satellite dependent response to proteotoxic stress","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Krembil Foundation; Canadian Institutes of Health Research; European Commission","keywords":"Aggresome; Centrosome; Cell biology; Biology; Microtubule; Ciliopathies; Microtubule organizing center; Cilium; Centriole; Proteostasis; Ubiquitin; Chemistry; Cell; Cell cycle; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024882,0.0003667733,0.0001634423,0.0001535128,0.0001588075,0.0003879938,0.0002560057,0.0002181763,0.0008050454],"category_scores_gemma":[0.0001025274,0.0001625452,0.0001367952,0.0001206147,0.0002676892,0.0001568785,0.0003222598,0.000383327,0.0006748902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004491103,"about_ca_system_score_gemma":0.0001955415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000463015,"about_ca_topic_score_gemma":0.00063326,"domain_scores_codex":[0.9999149,0.000008568876,0.00000643974,0.00001864816,0.00002850099,0.0000229233],"domain_scores_gemma":[0.9998877,0.00001249619,0.00003337461,0.00001321508,0.000009704546,0.00004355734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000681428,0.000009760312,0.0001486831,0.000007855176,0.000001479713,0.00008085516,0.000004911595,0.00007456011,0.9991787,0.00007313061,0.00002943185,0.0003225243],"study_design_scores_gemma":[0.00001161779,0.0000567192,0.006220452,0.000003434511,0.00000500064,0.0001830761,0.00001792343,0.002328646,0.9900473,0.00005450036,0.001067931,0.000003576937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969358,0.0001729396,0.001661408,0.00004044868,0.00001105377,0.00001671387,0.0003360858,0.00009605401,0.0007294645],"genre_scores_gemma":[0.9954374,0.0001230105,0.001064649,0.00003372134,0.000003303836,0.00001780219,0.0007203809,0.00005366433,0.002545973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008050454,"threshold_uncertainty_score":0.003258526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532064569732318,"score_gpt":0.2284208025034429,"score_spread":0.2131001568061197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}