{"id":"W3115597636","doi":"10.1158/2159-8290.cd-20-0387","title":"Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; NIH Office of the Director; University of California, San Diego; Weill Cornell Medical College; Genentech; National Institutes of Health; Celgene; Queen's University; Queen's University Belfast; Academy of Medical Sciences; Cancer Research UK; Ludwig Institute for Cancer Research; Swim Across America; Parker Institute for Cancer Immunotherapy; Robertson Foundation; Francis Crick Institute; Burroughs Wellcome Fund; Prostate Cancer Foundation; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation; Sanofi; AstraZeneca; Pfizer; Public Health Agency; Friends of the Cancer Centre; GlaxoSmithKline","keywords":"Immune system; Metastasis; Innate immune system; Cancer research; Biology; Immunotherapy; Extracellular; Inflammation; Cancer cell; Cancer immunotherapy; CCL18; Cancer; Cell biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055998,0.0002498592,0.0001220921,0.0001434527,0.0000820714,0.0002731963,0.0001267109,0.0002266646,0.0008115994],"category_scores_gemma":[0.00009857934,0.00008053995,0.0001089573,0.00007235142,0.0002297559,0.000188085,0.000189313,0.0004249527,0.0002412505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663412,"about_ca_system_score_gemma":0.0001188932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002059139,"about_ca_topic_score_gemma":0.0002895073,"domain_scores_codex":[0.9999284,0.00001113659,0.000004684814,0.0000114385,0.00002742692,0.00001697416],"domain_scores_gemma":[0.9999379,0.00001035884,0.00002577513,0.000005955889,0.000006552903,0.00001342983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004839569,0.000007202686,0.0001719744,0.00002000553,0.000001598721,0.0000981521,0.000004936271,0.00005723797,0.99756,0.0003248555,0.00005299071,0.001652662],"study_design_scores_gemma":[0.000007078214,0.0001007457,0.003212423,0.000004703668,0.000004480082,0.0007506612,0.00001551053,0.0005920006,0.9922504,0.000139901,0.002919576,0.000002406118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830698,0.006087746,0.005640152,0.0004373617,0.00006080075,0.00001848705,0.0001536657,0.00008769991,0.004444354],"genre_scores_gemma":[0.9953993,0.001062968,0.001022088,0.0000422657,0.00001652505,0.000006617638,0.0001120223,0.00000810898,0.002330187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008115994,"threshold_uncertainty_score":0.002715111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133506582022331,"score_gpt":0.24298850477369,"score_spread":0.2216534389534667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}