{"id":"W3115597636","doi":"10.1158/2159-8290.cd-20-0387","title":"Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; NIH Office of the Director; University of California, San Diego; Weill Cornell Medical College; Genentech; National Institutes of Health; Celgene; Queen's University; Queen's University Belfast; Academy of Medical Sciences; Cancer Research UK; Ludwig Institute for Cancer Research; Swim Across America; Parker Institute for Cancer Immunotherapy; Robertson Foundation; Francis Crick Institute; Burroughs Wellcome Fund; Prostate Cancer Foundation; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation; Sanofi; AstraZeneca; Pfizer; Public Health Agency; Friends of the Cancer Centre; GlaxoSmithKline","keywords":"Immune system; Metastasis; Innate immune system; Cancer research; Biology; Immunotherapy; Extracellular; Inflammation; Cancer cell; Cancer immunotherapy; CCL18; Cancer; Cell biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000807246,0.0001884472,0.0003624243,0.0000419507,0.0001144136,0.00004745183,0.0001704157,0.0001290373,0.00194297],"category_scores_gemma":[0.00006950201,0.000156054,0.0001401679,0.00009806509,0.0001504057,0.0002701719,0.0001391349,0.0002204669,0.000269404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003117535,"about_ca_system_score_gemma":0.00005636844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005399713,"about_ca_topic_score_gemma":0.00001116825,"domain_scores_codex":[0.9989323,0.000184375,0.0002566306,0.0003493149,0.00003494417,0.0002424409],"domain_scores_gemma":[0.9995019,0.000134241,0.00009121844,0.0002198101,0.00002248164,0.00003037188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008146459,0.00003016064,0.0005607625,0.00001583928,0.0004235373,0.000006982888,0.0006164503,0.000007396586,0.9837622,0.0001320922,0.001573835,0.01205609],"study_design_scores_gemma":[0.001123302,0.0001498084,0.003610374,0.00005327309,0.0001992755,0.000006144569,0.0004973307,0.0000354966,0.8976777,0.00005792941,0.09634247,0.0002469309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8603845,0.1365516,0.000474347,0.001514124,0.0004375596,0.0001322388,0.0001936138,0.00004599657,0.0002659543],"genre_scores_gemma":[0.9937161,0.002348278,0.00002350252,0.0005670046,0.0000597061,0.00003303708,0.0001110283,0.00002102632,0.003120381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1342033,"threshold_uncertainty_score":0.9989694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133506582022331,"score_gpt":0.24298850477369,"score_spread":0.2216534389534667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}