{"id":"W3115599474","doi":"10.21203/rs.3.rs-17223/v1","title":"A novel bifunctional aldehyde/alcohol dehydrogenase mediating ethanol formation from acetyl-CoA in hyperthermophiles","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Acetaldehyde; Hyperthermophile; Chemistry; Alcohol dehydrogenase; Ethanol; Aldehyde dehydrogenase; Biochemistry; Acetic acid; Fermentation; Alcohol; Ethanol fermentation; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.006248233,0.0007980358,0.0008657132,0.002735606,0.0006095899,0.0005611341,0.001564433,0.001433923,0.0009332102],"category_scores_gemma":[0.002194007,0.0008008085,0.0004036489,0.002703879,0.000540586,0.0007081442,0.002288857,0.009284253,0.001318594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002194893,"about_ca_system_score_gemma":0.0008308566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002404206,"about_ca_topic_score_gemma":0.0003504546,"domain_scores_codex":[0.9878698,0.001590898,0.001208553,0.00178224,0.00529174,0.002256791],"domain_scores_gemma":[0.9945781,0.001577788,0.0001393328,0.001395059,0.00140197,0.0009077154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008088354,0.000925529,0.001348317,0.01024504,0.0004649196,0.0003121041,0.007335249,0.01914004,0.9053887,0.0002336896,0.03030039,0.02349718],"study_design_scores_gemma":[0.006531918,0.000992388,0.005669245,0.00418978,0.0000597808,0.00005918521,0.008068653,0.5751638,0.3298965,0.009634118,0.05672807,0.003006613],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523081,0.008274607,0.003958737,0.01789176,0.002472773,0.007912439,0.0024791,0.001779117,0.002923331],"genre_scores_gemma":[0.9891834,0.003040187,0.001286069,0.00008267698,0.002462386,0.001073592,0.002515481,0.0002360945,0.0001200782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5754922,"threshold_uncertainty_score":0.9999801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1637349796035541,"score_gpt":0.3682927564399204,"score_spread":0.2045577768363664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}