{"id":"W3115627231","doi":"10.1021/acscatal.0c04520","title":"Catalytic Enantioselective Synthesis of a <i>cis</i>-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp<sup>3</sup>–Csp<sup>2</sup> Cross-Coupling to Access Elusive <i>trans</i>-β-Aryl/Heteroaryl Cyclobutylcarboxyesters","year":2020,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Chemistry; Cyclobutanes; Enantioselective synthesis; Combinatorial chemistry; Aryl; Steric effects; Catalysis; Ligand (biochemistry); Stereochemistry; Cycloaddition; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0004571691,0.002056954,0.002846932,0.0005418683,0.0005998196,0.0007592812,0.002345145,0.001078122,0.0003545814],"category_scores_gemma":[0.001219212,0.002153767,0.0009604165,0.002770573,0.0006481431,0.001948876,0.001523343,0.001147012,0.0001302486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006980528,"about_ca_system_score_gemma":0.0005777339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007254342,"about_ca_topic_score_gemma":0.00006120419,"domain_scores_codex":[0.9902995,0.00009268266,0.00231708,0.003541172,0.001611564,0.002138059],"domain_scores_gemma":[0.9932037,0.001163945,0.001018862,0.00202886,0.0008983649,0.001686278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001267321,0.0005926904,0.01470126,0.00179598,0.002746623,0.0002234922,0.01177423,0.004627053,0.9603803,0.00001083958,0.0004327997,0.001447393],"study_design_scores_gemma":[0.002732445,0.0001413129,0.0009212316,0.0004293412,0.002003541,0.0001142851,0.00188763,0.005872051,0.9833558,0.00001363673,0.000360684,0.002168041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927682,0.001123513,0.0001114149,0.001426754,0.0000994135,0.00102311,0.001791058,0.0005448389,0.001111642],"genre_scores_gemma":[0.9954187,0.0004412181,0.0001082057,0.001418289,0.0006149806,0.0004425565,0.0007336423,0.0004801042,0.0003423129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02297549,"threshold_uncertainty_score":0.9992172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173053978166191,"score_gpt":0.247587434125006,"score_spread":0.2358568943433441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}