{"id":"W3115627231","doi":"10.1021/acscatal.0c04520","title":"Catalytic Enantioselective Synthesis of a <i>cis</i>-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp<sup>3</sup>–Csp<sup>2</sup> Cross-Coupling to Access Elusive <i>trans</i>-β-Aryl/Heteroaryl Cyclobutylcarboxyesters","year":2020,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Chemistry; Cyclobutanes; Enantioselective synthesis; Combinatorial chemistry; Aryl; Steric effects; Catalysis; Ligand (biochemistry); Stereochemistry; Cycloaddition; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780861,0.0005721707,0.0003143864,0.0001371153,0.0001431867,0.0003479419,0.0003882713,0.0002868866,0.002199332],"category_scores_gemma":[0.0001561033,0.0002099546,0.0002667483,0.0002159733,0.0001567003,0.000371432,0.0004198556,0.000729721,0.001275664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285008,"about_ca_system_score_gemma":0.0003819959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006655609,"about_ca_topic_score_gemma":0.001399736,"domain_scores_codex":[0.9998717,0.00001208898,0.00001128849,0.00003104798,0.00002590937,0.00004788171],"domain_scores_gemma":[0.9999443,0.000005806036,0.00001575503,0.000007141424,0.00001041797,0.00001667284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001970713,0.00008357529,0.000221755,0.0003158819,0.00002572978,0.0003669376,0.00009160044,0.001135114,0.9823977,0.001801565,0.000665141,0.01269782],"study_design_scores_gemma":[0.00003412987,0.0002498406,0.000335723,0.00001269366,0.00001611996,0.0002422372,0.00003176061,0.001235686,0.9917268,0.0001130522,0.005985382,0.00001661606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.928958,0.003107133,0.03311663,0.0004557649,0.0001539392,0.0002096831,0.001314847,0.0005298853,0.03215408],"genre_scores_gemma":[0.9822535,0.002027532,0.009214225,0.000105953,0.00001101773,0.0000713894,0.0007578646,0.0001028904,0.005455623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199332,"threshold_uncertainty_score":0.007357478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173053978166191,"score_gpt":0.247587434125006,"score_spread":0.2358568943433441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}