{"id":"W3115643961","doi":"10.1002/bip.23414","title":"The evolutionary background and functional consequences of the rs2071307 polymorphism in human tropoelastin","year":2020,"lang":"en","type":"article","venue":"Biopolymers","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; ProteinQure (Canada); Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Tropoelastin; Elastin; Chemistry; Radius of gyration; Biophysics; Population; Loss of heterozygosity; Polymorphism (computer science); Allele; Polymer; Genetics; Stereochemistry; Biochemistry; Biology; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123667,0.0003941732,0.0002219742,0.0003643616,0.0001751185,0.0001772592,0.0001334555,0.0005309724,0.001738855],"category_scores_gemma":[0.0003953188,0.0001063252,0.0002764031,0.0003499592,0.0002439935,0.00007155269,0.0001590534,0.0003423496,0.000169107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008687188,"about_ca_system_score_gemma":0.00008834428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007431712,"about_ca_topic_score_gemma":0.000637742,"domain_scores_codex":[0.9997869,0.00006760722,0.00001555835,0.00007210677,0.00003632973,0.00002139964],"domain_scores_gemma":[0.999855,0.00005700533,0.00003780297,0.00001195873,0.000006563993,0.00003163492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00364853,0.0002369568,0.07598862,0.0001249227,0.0003344442,0.009329893,0.0003320093,0.001079318,0.8917275,0.001037771,0.0004486599,0.01571141],"study_design_scores_gemma":[0.0001940376,0.001757202,0.8771429,0.00004280009,0.0005925303,0.0252963,0.00023477,0.005309212,0.0845286,0.00130458,0.003522347,0.00007472851],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983871,0.0002059218,0.0006695684,0.00006265066,0.00001248532,0.000007427795,0.0002475819,0.00001392206,0.0003934092],"genre_scores_gemma":[0.9990232,0.00008173002,0.0004307939,0.00003154852,0.00001246128,0.00001006221,0.0001559346,0.00001228614,0.0002419247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001738855,"threshold_uncertainty_score":0.005816996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808194679648919,"score_gpt":0.2834581990130659,"score_spread":0.2453762522165767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}