{"id":"W3115651269","doi":"10.1158/1078-0432.ccr-20-2563","title":"LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mood Disorders Association of British Columbia; Aegera Therapeutics (Canada)","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; KRAS; In vivo; Biology; Cancer research; Mutant; MAPK/ERK pathway; Kinase; Cell culture; Mutation; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000341083,0.00007862941,0.0002171153,0.00001777105,0.00006732711,0.000008846512,0.00009983652,0.00008681327,0.000004364355],"category_scores_gemma":[0.0002772717,0.00005233084,0.00008022971,0.00007300045,0.0003151582,0.000001904088,0.0001065866,0.00009842481,3.721844e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000118657,"about_ca_system_score_gemma":0.0001566646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001121874,"about_ca_topic_score_gemma":0.00009150099,"domain_scores_codex":[0.9990156,0.0001044173,0.00026006,0.0003023954,0.0001328926,0.0001846731],"domain_scores_gemma":[0.9992103,0.0002812528,0.00006503297,0.000151235,0.0001710447,0.0001211661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006000933,0.0006879275,0.1519182,0.0005550864,0.0007141831,0.00001527105,0.001620424,0.00008462014,0.6517745,0.0003580395,0.005454129,0.1808166],"study_design_scores_gemma":[0.005562606,0.02221432,0.08129831,0.000103106,0.0001030787,0.000006392432,0.0006145262,0.001802872,0.8334768,0.0002657089,0.05429011,0.0002621813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948496,0.00319542,0.000153346,0.001034017,0.00004591045,0.0005473553,0.00005753742,0.0000023773,0.0001144338],"genre_scores_gemma":[0.9956968,0.0034784,0.0001506793,0.0000719755,0.0003734085,0.0001151689,0.000006805889,0.00001074998,0.0000959656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1817022,"threshold_uncertainty_score":0.213399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.19876116464915,"score_gpt":0.4547302721206311,"score_spread":0.255969107471481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}