{"id":"W3115713778","doi":"10.1093/neuonc/noaa306","title":"Modeling human brain tumors in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets","year":2020,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Zebrafish; Biology; Danio; Model organism; Caenorhabditis elegans; Computational biology; Drosophila melanogaster; Genome; RNA interference; Neuroscience; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001587094,0.000369347,0.001212117,0.0001252324,0.00003103917,0.00001172492,0.0003193147,0.0004153269,0.00001098743],"category_scores_gemma":[0.0001451956,0.0003525041,0.000152389,0.0001647661,0.00004369915,0.000002408918,0.0003630718,0.000364878,0.000002425898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004774167,"about_ca_system_score_gemma":0.0002670247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003620934,"about_ca_topic_score_gemma":0.0001936097,"domain_scores_codex":[0.9981413,0.0001042877,0.0006494624,0.0006828668,0.0001070437,0.000315009],"domain_scores_gemma":[0.999261,0.00007279505,0.0001370086,0.0003544651,0.00003295214,0.0001418218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000579702,0.0002301656,0.00001977365,0.002405787,0.0001829427,0.00005495055,0.0003676112,0.002685625,0.4509464,0.0000717916,0.0002687305,0.5427083],"study_design_scores_gemma":[0.0005157095,0.0005989404,0.000006926596,0.0004100503,0.00009079033,0.00003112596,0.00002073319,0.0007885249,0.004352255,0.00002022127,0.9928368,0.0003278916],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004415065,0.9875484,0.006437984,0.0001712332,0.0002283735,0.0009675331,0.0001020829,0.00001571624,0.0001135982],"genre_scores_gemma":[0.03545217,0.9589878,0.002569467,0.001163414,0.0006469195,0.0002926111,0.0006309541,0.0002126931,0.00004398677],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9925681,"threshold_uncertainty_score":0.9998927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03541518766050802,"score_gpt":0.3599964333821772,"score_spread":0.3245812457216692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}