{"id":"W3115758135","doi":"10.1093/nar/gkaa1176","title":"Identification of lysine isobutyrylation as a new histone modification mark","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Science Foundation; National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Biology; Lysine; Histone; Biochemistry; Acetylation; Histone H3; Epigenetics; Cell biology; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006873049,0.0001946507,0.0001563856,0.0001747677,0.00012877,0.0001976952,0.000133509,0.0002161325,0.0006930359],"category_scores_gemma":[0.0000650724,0.0001002168,0.0001930001,0.0001891486,0.0001539985,0.0001894546,0.0001807489,0.0003653132,0.0002582668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002348945,"about_ca_system_score_gemma":0.0001520622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468651,"about_ca_topic_score_gemma":0.001129929,"domain_scores_codex":[0.9999534,0.000004079752,0.000002646136,0.00001724024,0.00001394089,0.000008716686],"domain_scores_gemma":[0.9999431,0.000004871313,0.00001863416,0.000007040145,0.00001000864,0.00001639137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005177691,0.000004083747,0.0006893719,0.00003058569,0.00000453473,0.00005757504,0.000009767703,0.00004258203,0.9965112,0.0001402655,0.00002865152,0.002429627],"study_design_scores_gemma":[0.000005796737,0.0001061141,0.01753955,0.000005389485,0.00001919604,0.0005264093,0.00003700853,0.0008800396,0.9751604,0.0002384287,0.005472251,0.000009374917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738119,0.007944637,0.01543877,0.0002516925,0.00004786104,0.00001966335,0.0005283096,0.000154533,0.001802739],"genre_scores_gemma":[0.9882085,0.002437643,0.005895967,0.00008766569,0.00001447108,0.000008178034,0.000848944,0.00001567583,0.002482982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006930359,"threshold_uncertainty_score":0.002318382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06010166253354328,"score_gpt":0.3787860512284054,"score_spread":0.3186843886948621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}