{"id":"W3115758135","doi":"10.1093/nar/gkaa1176","title":"Identification of lysine isobutyrylation as a new histone modification mark","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Science Foundation; National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Biology; Lysine; Histone; Biochemistry; Acetylation; Histone H3; Epigenetics; Cell biology; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004432775,0.00008557154,0.0001061241,0.00008240505,0.0001094056,0.00003278865,0.0003050098,0.0001201794,0.0001812283],"category_scores_gemma":[0.000507143,0.00008956971,0.00005987408,0.0004331489,0.0001192515,0.00001183728,0.00008067356,0.0001334762,0.0001910277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004355226,"about_ca_system_score_gemma":0.0002819344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007600681,"about_ca_topic_score_gemma":0.00000321648,"domain_scores_codex":[0.9986076,0.000109547,0.000313183,0.0003690848,0.0004102889,0.0001903314],"domain_scores_gemma":[0.9988285,0.00001240799,0.0001105729,0.0004615167,0.0004079277,0.0001790162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384122,0.00004430163,0.000280553,0.00002208303,0.000018254,2.572248e-7,0.0001959767,0.00009425383,0.964254,0.001049689,0.01819256,0.01570966],"study_design_scores_gemma":[0.0006397337,0.0003675148,0.008690687,0.00001101227,0.00001615063,0.000002681846,0.0002714703,0.004077089,0.8913057,0.0006719754,0.09376899,0.0001769257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631064,0.0009211962,0.02402735,0.008087735,0.00005903838,0.000415381,0.00002131908,0.00002116031,0.003340426],"genre_scores_gemma":[0.9947937,0.0003698389,0.0005252919,0.0001402892,0.0002714567,0.00003261201,0.0001461178,0.00002213609,0.003698549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07557643,"threshold_uncertainty_score":0.3652547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06010166253354328,"score_gpt":0.3787860512284054,"score_spread":0.3186843886948621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}