{"id":"W3115817617","doi":"10.21203/rs.3.rs-68257/v1","title":"Prioritization of candidate causal genes in GWAS signals of asthma in UK Biobank","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Canadian Institutes of Health Research; Université Laval","keywords":"Genome-wide association study; Asthma; Candidate gene; Biology; Gene; Quantitative trait locus; Genetics; Locus (genetics); Genetic association; Biobank; Computational biology; Immunology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004481399,0.0004360309,0.001234333,0.003628699,0.0007981943,0.001409245,0.000739134,0.0008093073,0.008250428],"category_scores_gemma":[0.01921367,0.0003072845,0.0006713725,0.004776711,0.0004189882,0.0004893083,0.001762361,0.000588468,0.0008656761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005506785,"about_ca_system_score_gemma":0.0006378268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01329843,"about_ca_topic_score_gemma":0.01648648,"domain_scores_codex":[0.9940543,0.002816864,0.000759113,0.001124877,0.0006636796,0.00058114],"domain_scores_gemma":[0.9888564,0.006337507,0.002246009,0.001047046,0.001000924,0.0005121641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001443021,0.00006050841,0.9536195,0.0003507375,0.0005995755,0.001790978,0.0006038445,0.0006239217,0.01584444,0.0008203956,0.006790375,0.01745271],"study_design_scores_gemma":[0.00020163,0.0001146045,0.9881073,0.0001030599,0.0003450484,0.001027805,0.0003431124,0.002454629,0.001901412,0.0004988767,0.004878847,0.00002371773],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869598,0.001501891,0.00308618,0.0006048144,0.00007236585,0.00009544762,0.00583655,0.000089811,0.001753255],"genre_scores_gemma":[0.9909147,0.0002104986,0.003226357,0.0003497903,0.00004622115,0.0001020236,0.004427086,0.00003659317,0.0006867423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01329843,"threshold_uncertainty_score":0.02760041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06242666381772808,"score_gpt":0.4059194530284166,"score_spread":0.3434927892106885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}