{"id":"W3115825159","doi":"10.1093/molbev/msaa323","title":"Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence","year":2020,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Biotechnology and Biological Sciences Research Council; Royal Society; University of Cambridge; Wellcome Trust; Newnham College, University of Cambridge; Energy Biosciences Institute","keywords":"Biology; Genome; Pathogenicity island; Pathogenicity; Genome size; Bacterial genome size; Genome evolution; Genetics; Gene; Evolutionary biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311976,0.0001418788,0.0002528898,0.0009107821,0.0001877999,0.0003841778,0.0001667335,0.0002901368,0.001631314],"category_scores_gemma":[0.0009949853,0.0001202481,0.0002247672,0.0007491205,0.0003546163,0.0003258158,0.0005030825,0.000432643,0.0001884476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623184,"about_ca_system_score_gemma":0.0001448493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005805718,"about_ca_topic_score_gemma":0.0008828898,"domain_scores_codex":[0.9997002,0.00005570062,0.00001933886,0.00009569126,0.00006908941,0.00006007013],"domain_scores_gemma":[0.9989799,0.0002256278,0.0004899998,0.00009698356,0.0001030981,0.0001043419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006753025,0.00007096204,0.3732762,0.0001067201,0.0001629767,0.000203896,0.0003705718,0.000343596,0.6078112,0.0003156746,0.0001273991,0.0165355],"study_design_scores_gemma":[0.000001809153,0.0001409144,0.9930363,0.000003328036,0.00001654072,0.0002546013,0.0001781493,0.0001964734,0.005644261,0.0001665945,0.0003564878,0.000004421268],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978464,0.0005402218,0.0007368073,0.00004135726,0.000003061521,0.000004010263,0.0001763402,0.00001419798,0.000637531],"genre_scores_gemma":[0.9990345,0.0001326443,0.0003510328,0.00002498384,0.000004256175,0.00000596531,0.000235077,0.000005484757,0.0002060284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631314,"threshold_uncertainty_score":0.005457282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525324592969814,"score_gpt":0.2756614807728488,"score_spread":0.2604082348431507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}