{"id":"W3115865218","doi":"10.1038/s41598-021-89004-x","title":"Highly specific and ultrasensitive plasma test detects Abeta(1–42) and Abeta(1–40) in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"GIESKES-STRIJBIS FONDS; Amsterdam Neuroscience; Alzheimer Nederland; ZonMw; Health~Holland; European Commission; EU Joint Programme – Neurodegenerative Disease Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute","keywords":"Biomarker; Medicine; Internal medicine; Molecular biology; Chemistry; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001070086,0.0006976154,0.0003854072,0.0006409205,0.0001734823,0.0004691122,0.0003459576,0.0007031042,0.001911252],"category_scores_gemma":[0.001146056,0.0003691398,0.0002033031,0.0003105735,0.0003001816,0.0003010138,0.000315839,0.0007310957,0.0007167588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507013,"about_ca_system_score_gemma":0.0001332702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002791204,"about_ca_topic_score_gemma":0.0004682096,"domain_scores_codex":[0.9991014,0.0002846441,0.00006458377,0.0002546979,0.0002310631,0.00006363028],"domain_scores_gemma":[0.9992537,0.0002900566,0.0001520222,0.00005802339,0.0001728877,0.00007340911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001109435,0.000383413,0.03002902,0.0001433434,0.00006800851,0.0002412349,0.0001671074,0.0001622974,0.9450788,0.0001371027,0.0006960207,0.02178421],"study_design_scores_gemma":[0.0001216708,0.005093668,0.2127034,0.00005651019,0.0001634099,0.006998408,0.0002803984,0.006266415,0.7633933,0.000393379,0.004477079,0.0000523781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759638,0.002117166,0.01852872,0.00008585687,0.00009880907,0.0001000781,0.0003520016,0.0004113952,0.002342172],"genre_scores_gemma":[0.9721482,0.000476984,0.02246927,0.0001949994,0.00006326624,0.0001815638,0.000582063,0.00002979936,0.003853817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911252,"threshold_uncertainty_score":0.00639379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257494873774619,"score_gpt":0.2817480512566948,"score_spread":0.2559985638792329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}