{"id":"W3115869600","doi":"10.3324/haematol.2020.271908","title":"CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide","year":2020,"lang":"en","type":"article","venue":"Haematologica","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science Foundation Ireland; Irish Cancer Society; Health Research Board; Health Service Executive; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"CD38; Chimeric antigen receptor; Myeloid leukemia; Cancer research; Leukemia; Interleukin 12; Lymphokine-activated killer cell; Biology; Cytotoxic T cell; Immunology; Immunotherapy; Interleukin 21; Antigen; Cell biology; Stem cell; Immune system; CD8; CD34; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046981,0.0002669852,0.000231414,0.0001272414,0.00009449478,0.0002482396,0.000177451,0.0002123641,0.001728959],"category_scores_gemma":[0.00008285059,0.0000895837,0.000134601,0.00007373837,0.0002094772,0.0001839757,0.0001906451,0.0005662946,0.000514298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318714,"about_ca_system_score_gemma":0.0001821315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003497389,"about_ca_topic_score_gemma":0.0005170938,"domain_scores_codex":[0.999866,0.00001430701,0.00001258024,0.0000279709,0.00004929138,0.000029696],"domain_scores_gemma":[0.9999498,0.000008152525,0.00001722856,0.000009171394,0.000004889404,0.00001069548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004367135,0.00001706838,0.0000639632,0.00001594683,0.000002091171,0.00004774545,0.0000101282,0.0001225809,0.9979937,0.0002012126,0.00005217563,0.001429761],"study_design_scores_gemma":[0.00001574994,0.0001377924,0.0007422374,0.000002153871,0.000007849771,0.0003286671,0.00001082546,0.000999918,0.9931492,0.00006656023,0.004536702,0.000002376278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982767,0.000582877,0.01326477,0.0001445398,0.00003229073,0.00006970309,0.0003846178,0.0003277867,0.002426423],"genre_scores_gemma":[0.9887405,0.0003345717,0.004853904,0.00003675271,0.000004698155,0.00004652536,0.000392555,0.00003908476,0.005551358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001728959,"threshold_uncertainty_score":0.005783916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117735817208965,"score_gpt":0.2238449929634395,"score_spread":0.2126676347913498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}