{"id":"W3115869600","doi":"10.3324/haematol.2020.271908","title":"CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide","year":2020,"lang":"en","type":"article","venue":"Haematologica","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science Foundation Ireland; Irish Cancer Society; Health Research Board; Health Service Executive; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"CD38; Chimeric antigen receptor; Myeloid leukemia; Cancer research; Leukemia; Interleukin 12; Lymphokine-activated killer cell; Biology; Cytotoxic T cell; Immunology; Immunotherapy; Interleukin 21; Antigen; Cell biology; Stem cell; Immune system; CD8; CD34; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001795069,0.0005718812,0.0009649014,0.0001402376,0.0005913244,0.0001094687,0.0005196087,0.000510951,0.00562018],"category_scores_gemma":[0.00009924623,0.0004191185,0.0002393097,0.0004123797,0.0002377894,0.0005021891,0.0001637682,0.001086285,0.002447861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001036318,"about_ca_system_score_gemma":0.0001577276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008184361,"about_ca_topic_score_gemma":0.000002032637,"domain_scores_codex":[0.9969282,0.0007572005,0.0006086448,0.0008859905,0.0001084572,0.0007115578],"domain_scores_gemma":[0.9985055,0.0002139748,0.0005113432,0.000478409,0.0001680939,0.0001227235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003694042,0.0001601072,0.0002367762,0.00004502882,0.0002778883,0.00005380988,0.0007188129,0.0001875259,0.9448867,0.000006847345,0.04939263,0.0003398371],"study_design_scores_gemma":[0.002941793,0.001076638,0.0007699432,0.0000517807,0.0001453339,0.0001742846,0.0005090483,0.0002384281,0.948741,0.000003063951,0.04470794,0.0006407984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875085,0.001822507,0.001095188,0.0004266353,0.005704547,0.0007362331,0.00001378011,0.0005767589,0.002115897],"genre_scores_gemma":[0.9880061,0.000250557,0.005704325,0.001162592,0.000109939,0.0000633536,0.0006988393,0.0000642878,0.003940025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005594607,"threshold_uncertainty_score":0.9998261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117735817208965,"score_gpt":0.2238449929634395,"score_spread":0.2126676347913498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}