{"id":"W3115895448","doi":"10.1101/2020.12.24.423824","title":"CLN5 and CLN3 function as a complex to regulate endolysosome function","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; Institut National de la Recherche Scientifique","funders":"Universitätsklinikum Hamburg-Eppendorf; Peking University; National Institutes of Health; Queen Mary University of London","keywords":"Retromer; Endosome; Cell biology; Endocytic cycle; Biology; Batten disease; Golgi apparatus; Transport protein; Endocytosis; Receptor; Biochemistry; Endoplasmic reticulum; Intracellular; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002526083,0.000448049,0.0001691731,0.0001911196,0.0002719868,0.0005091228,0.000416307,0.0003636759,0.00102184],"category_scores_gemma":[0.0001750283,0.0001183791,0.0003534554,0.000100585,0.0002019004,0.0002821287,0.0004575944,0.0002507484,0.0004610777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001561395,"about_ca_system_score_gemma":0.0003553417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001862964,"about_ca_topic_score_gemma":0.002315072,"domain_scores_codex":[0.9997951,0.00003157528,0.00002398339,0.00004998067,0.00006028773,0.00003908702],"domain_scores_gemma":[0.9998786,0.000009700932,0.00003973564,0.00001375047,0.00002398619,0.00003426838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001539714,0.000009289012,0.001244636,0.00004061982,0.00001053587,0.0001277053,0.00001626506,0.000191462,0.9966556,0.0003047125,0.0001216721,0.001123499],"study_design_scores_gemma":[0.00002848862,0.00008645833,0.01883534,0.00002665728,0.00002502133,0.0005794911,0.00007974978,0.007973549,0.9665835,0.0002241594,0.00554514,0.00001244642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856222,0.003877612,0.007740853,0.0001866115,0.00004618927,0.00002512963,0.0004412106,0.0001177933,0.001942418],"genre_scores_gemma":[0.9957919,0.0003180786,0.001970349,0.00007895961,0.000003528466,0.00001652646,0.0004668119,0.0000160085,0.001337746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001862964,"threshold_uncertainty_score":0.0113287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542386243934795,"score_gpt":0.2091961479010785,"score_spread":0.1937722854617305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}