{"id":"W3115957999","doi":"10.21203/rs.3.rs-26489/v1","title":"Anti Hepatitis C virus drugs show potential drug repositioning for SARS CoV-2 main protease: an in silico study","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Simeprevir; Boceprevir; Paritaprevir; Dasabuvir; Virology; Telaprevir; Ombitasvir; Drug repositioning; Ledipasvir; Drug; In silico; Medicine; Pharmacology; Hepatitis C virus; Virus; Biology; Ribavirin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005707358,0.0006468894,0.0009945011,0.0006304534,0.0003281178,0.0006707077,0.0004439927,0.0005553915,0.005660096],"category_scores_gemma":[0.0011388,0.0002867037,0.001475675,0.0006666826,0.0001846576,0.0004061731,0.000252506,0.0005224322,0.0004934288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398562,"about_ca_system_score_gemma":0.0007175591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004188755,"about_ca_topic_score_gemma":0.00597153,"domain_scores_codex":[0.9997963,0.0000928924,0.00001144019,0.00002960051,0.00003927809,0.00003046224],"domain_scores_gemma":[0.9988711,0.0008936551,0.00007208924,0.00003645954,0.00009144563,0.00003525136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001122992,0.001085464,0.02093845,0.001074644,0.0008129764,0.0007548248,0.00005424711,0.9334027,0.01462993,0.002908899,0.003096552,0.02011822],"study_design_scores_gemma":[0.000177926,0.00100812,0.003542935,0.00004580158,0.0003130489,0.0002960069,0.00005789801,0.9843518,0.006708417,0.0009887166,0.002485686,0.00002357587],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970674,0.004319808,0.01178465,0.0007303148,0.00008494156,0.0001056007,0.002293301,0.0002477535,0.009759558],"genre_scores_gemma":[0.9824091,0.002193929,0.01094187,0.0001349409,0.0000248131,0.0000568605,0.002346424,0.00002946721,0.001862507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005660096,"threshold_uncertainty_score":0.01893491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1355890102167583,"score_gpt":0.4677453364064382,"score_spread":0.3321563261896799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}