{"id":"W3116039732","doi":"10.1021/acs.jmedchem.0c01547","title":"Structure–Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke; Canadian Institutes of Health Research; Mitacs; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Apelin; Chemistry; Receptor; Docking (animal); Stereochemistry; In vivo; Structure–activity relationship; Biochemistry; In vitro; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008563179,0.0001485989,0.0006741437,0.0000630901,0.00003710775,0.000002981921,0.0002462807,0.0002831709,0.0002646687],"category_scores_gemma":[0.00663952,0.00009176153,0.0001796815,0.0004803703,0.0009067183,0.00006381931,0.00009835082,0.001340828,6.137769e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007134968,"about_ca_system_score_gemma":0.0007030315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002742405,"about_ca_topic_score_gemma":0.000001184619,"domain_scores_codex":[0.9973505,0.0001060681,0.0007769373,0.0001633096,0.001430513,0.0001726526],"domain_scores_gemma":[0.9975023,0.0006148005,0.0007297649,0.0002255793,0.0005268499,0.0004007671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001291631,0.0001482551,0.04929245,0.0009109956,0.0002152366,0.00002584873,0.0003021378,0.000001777138,0.9438906,0.00001251,0.0004665148,0.00344205],"study_design_scores_gemma":[0.001467865,0.0007323473,0.1574426,0.0008735521,0.0003395547,0.0002888906,0.0004713732,0.0001097885,0.8377346,0.0002375065,0.0002243227,0.00007755139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916801,0.001017936,0.00008362812,0.006496013,0.00006361229,0.0001178225,0.00003177189,0.000003823829,0.0005053286],"genre_scores_gemma":[0.999029,0.0002191583,0.0003155874,0.0000814054,0.0002745736,3.813123e-7,0.000004899068,0.00001254855,0.00006245166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1081502,"threshold_uncertainty_score":0.7948605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417858920118885,"score_gpt":0.3194354572417916,"score_spread":0.2852568680406028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}