{"id":"W3116039732","doi":"10.1021/acs.jmedchem.0c01547","title":"Structure–Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke; Canadian Institutes of Health Research; Mitacs; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Apelin; Chemistry; Receptor; Docking (animal); Stereochemistry; In vivo; Structure–activity relationship; Biochemistry; In vitro; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328309,0.0002590856,0.0002868875,0.0002012414,0.0001172638,0.000185497,0.000218174,0.0002028674,0.00147959],"category_scores_gemma":[0.0001897679,0.000101552,0.0003080504,0.0002049782,0.0001523707,0.0002052095,0.0001617812,0.000593775,0.0003247614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544211,"about_ca_system_score_gemma":0.0001420496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004062105,"about_ca_topic_score_gemma":0.0004785187,"domain_scores_codex":[0.9999385,0.0000120607,0.000006354064,0.00001022673,0.00001286965,0.00002006375],"domain_scores_gemma":[0.9998757,0.0000225774,0.00003239558,0.000008522251,0.00001459025,0.00004628501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001574342,0.0003050842,0.0003810537,0.0001386594,0.00004599718,0.0001677287,0.00003174821,0.001445988,0.990477,0.0001354131,0.0001108581,0.005186084],"study_design_scores_gemma":[0.0005847895,0.02099933,0.009870902,0.00002825136,0.0002070821,0.0009156142,0.00009736532,0.004869697,0.9526719,0.0001997778,0.00950264,0.00005272675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937454,0.004098605,0.0008281934,0.00005836403,0.00002192562,0.00003401845,0.0002811159,0.00001322639,0.0009191461],"genre_scores_gemma":[0.9946542,0.001973837,0.001345257,0.00006338494,0.00001517806,0.00002835329,0.0007401093,0.000004669322,0.001175083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00147959,"threshold_uncertainty_score":0.004949749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417858920118885,"score_gpt":0.3194354572417916,"score_spread":0.2852568680406028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}