{"id":"W3116060128","doi":"10.1186/s13643-021-01835-x","title":"Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions","year":2021,"lang":"en","type":"review","venue":"Systematic Reviews","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton; Impact","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Oxford","keywords":"Medicine; Hydroxychloroquine; Adverse effect; Meta-analysis; Odds ratio; Randomized controlled trial; Chloroquine; Placebo; Internal medicine; MEDLINE; Confidence interval; Clinical trial; Intensive care medicine; Disease; Malaria; Alternative medicine; Coronavirus disease 2019 (COVID-19); Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03189339,0.003194849,0.02699588,0.009858123,0.0008114513,0.004071114,0.002460674,0.002701255,0.004043887],"category_scores_gemma":[0.08972325,0.001714846,0.03640101,0.008976347,0.001111173,0.002222177,0.001838313,0.002292843,0.0003291461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004240075,"about_ca_system_score_gemma":0.006668881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005930648,"about_ca_topic_score_gemma":0.01278487,"domain_scores_codex":[0.9634195,0.01870681,0.01141199,0.002247615,0.00367675,0.0005373224],"domain_scores_gemma":[0.9348071,0.04890256,0.01036244,0.001577138,0.003834743,0.0005159804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001430522,0.00001888864,0.001480732,0.5446254,0.4417467,0.0001127235,0.00007293433,0.0003456556,0.0001362565,0.0001439647,0.0004807741,0.009405422],"study_design_scores_gemma":[0.0007597849,0.000219441,0.002180126,0.05432841,0.9402663,0.0001008876,0.00004065274,0.0001447207,0.0001107881,0.000225582,0.001600671,0.00002267407],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003616545,0.9937389,0.0006408375,0.0002213584,0.0002359206,0.0006614048,0.0005260569,0.00002425797,0.0003348503],"genre_scores_gemma":[0.1435191,0.8471438,0.003767424,0.001149225,0.0003333711,0.002604653,0.001136198,0.00003586936,0.000310443],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03189339,"threshold_uncertainty_score":0.1686704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09889138689305196,"score_gpt":0.3903643235353096,"score_spread":0.2914729366422576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}