{"id":"W3116103979","doi":"10.1002/hep.31695","title":"Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators","year":2020,"lang":"en","type":"article","venue":"Hepatology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University College London; National Institutes of Health; Cancer Research UK; Wellcome Trust; National Institute for Health and Care Research; Emory University","keywords":"Immunology; Immune system; Biology; Cytokine; CD8; Interferon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757932,0.0001949939,0.0006671936,0.0001301356,0.00005176678,0.000002802858,0.0002304594,0.0003934269,0.000164697],"category_scores_gemma":[0.00004163703,0.0001992005,0.00009068903,0.000178715,0.0007927316,0.00006653394,0.0001431803,0.000345268,0.00002292995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007642312,"about_ca_system_score_gemma":0.0002869765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007202832,"about_ca_topic_score_gemma":0.0003115705,"domain_scores_codex":[0.9983267,0.0002879227,0.0006065959,0.0003583039,0.00004884393,0.0003716643],"domain_scores_gemma":[0.999285,0.00009938954,0.0002655625,0.0002674506,0.00006170879,0.00002090563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003286005,0.00005418067,0.2080539,0.0002222686,0.000152403,0.00002288009,0.0009839281,0.00004530033,0.7793941,0.001381081,0.0002110749,0.009150318],"study_design_scores_gemma":[0.006056253,0.001069028,0.08057949,0.0001591758,0.0002154269,0.0001956625,0.0003076679,0.005825952,0.8980601,0.001001982,0.005859012,0.00067025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733301,0.0249237,0.0002346034,0.0004068928,0.0006553193,0.0001825392,0.00002273829,0.00002922201,0.0002149279],"genre_scores_gemma":[0.9969139,0.002645274,0.00008999934,0.0002237866,0.00003625912,0.000007862895,0.00002839374,0.00002633615,0.00002817573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1274744,"threshold_uncertainty_score":0.8123162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168295282583233,"score_gpt":0.2305624538767784,"score_spread":0.218879501050946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}