{"id":"W3116421092","doi":"10.1186/s12974-021-02158-3","title":"Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":218,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"O. E. och Edla Johanssons Vetenskapliga Stiftelse; Uppsala Universitet; Åhlén-stiftelsen; Demensförbundet; Vetenskapsrådet; Stiftelsen Olle Engkvist Byggmästare; Torsten Söderbergs Stiftelse; Stiftelsen Apotekare Hedbergs Fond för Medicinsk Forskning; Karolinska Institutet; Alzheimerfonden; Gun och Bertil Stohnes Stiftelse; Parkinsonfonden; Hjärnfonden","keywords":"Microglia; Crosstalk; Neuroscience; Amyloid β; Amyloid (mycology); Neurology; Neuroinflammation; Chemistry; Cell biology; Biology; Medicine; Inflammation; Immunology; Disease; Engineering; Internal medicine; Pathology; Electronic engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002353608,0.0004736015,0.0003475485,0.000252946,0.0003186712,0.0004787899,0.0001514142,0.0003469765,0.001152521],"category_scores_gemma":[0.0001372025,0.0001616238,0.0004280148,0.0002245825,0.0002191529,0.0002331061,0.0003389211,0.0003390048,0.0004623578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001819878,"about_ca_system_score_gemma":0.0002209729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021597,"about_ca_topic_score_gemma":0.0006971754,"domain_scores_codex":[0.9995183,0.00008346031,0.00004334198,0.00009778235,0.0001615819,0.00009553444],"domain_scores_gemma":[0.9998515,0.00002168858,0.00004749974,0.000011887,0.00003198857,0.00003544799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437613,0.00002330676,0.0007840072,0.00008040255,0.00001393118,0.0002247438,0.0000404945,0.00003161568,0.9974848,0.00004382539,0.00003382774,0.001095362],"study_design_scores_gemma":[0.0000175441,0.0005992759,0.02732823,0.00003070745,0.00008196288,0.001709822,0.0002815977,0.0007287236,0.9661679,0.0001470348,0.002898524,0.000008667285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910648,0.00392045,0.003142629,0.00009462407,0.00004386533,0.00002089712,0.0002463509,0.00005125312,0.001415268],"genre_scores_gemma":[0.9934464,0.001707294,0.003344279,0.00008123589,0.00002511787,0.00005099641,0.0002253787,0.00001216703,0.001107088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152521,"threshold_uncertainty_score":0.003855526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02376120475751027,"score_gpt":0.2914134460468856,"score_spread":0.2676522412893754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}