{"id":"W3116539163","doi":"10.1101/2020.12.18.423421","title":"Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Environmental Health Sciences; Helse Sør-Øst RHF; Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Institut pour la Recherche en Santé Publique; Novo Nordisk Fonden; Mutuelle Générale de l'Education Nationale; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; National Institute on Drug Abuse; Novo Nordisk; Juho Vainion Säätiö; Canadian Institutes of Health Research; Yrjö Jahnssonin Säätiö; Jane ja Aatos Erkon Säätiö; National Institute of Mental Health; Fondation pour la Recherche Médicale; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Päivikki ja Sakari Sohlbergin Säätiö; Suomen Lääketieteen Säätiö; Academy of Finland; Erasmus Universiteit Rotterdam; ZonMw; Institut National de la Santé et de la Recherche Médicale; Norges Forskningsråd; Erasmus Medisch Centrum; Centres de Recerca de Catalunya; University of Bristol; Deutsche Forschungsgemeinschaft; Helsingin Yliopisto; European Commission; Joint Programming Initiative A healthy diet for a healthy life; Jalmari ja Rauha Ahokkaan Säätiö; Fundació la Marató de TV3; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; CHIST-ERA; Agence Nationale de la Recherche; Université Paris-Sud; Emil Aaltosen Säätiö; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Epigenetics; DNA methylation; Epigenome; Cognition; Population; CpG site; Cord blood; Cognitive skill; Genetics; Developmental psychology; Psychology; Biology; Medicine; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01239687,0.001811601,0.005142023,0.003344153,0.0008649931,0.002483102,0.001585,0.00155139,0.003958243],"category_scores_gemma":[0.02593549,0.001000946,0.02379491,0.00548457,0.0005771712,0.0008296643,0.001439378,0.001911391,0.0003008494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006945226,"about_ca_system_score_gemma":0.001025502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007164609,"about_ca_topic_score_gemma":0.009320442,"domain_scores_codex":[0.9909051,0.005528192,0.0009886032,0.001809294,0.000476278,0.0002925414],"domain_scores_gemma":[0.9817949,0.01342286,0.001295817,0.00253283,0.0006292229,0.0003243049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003802766,0.00003288532,0.08856033,0.006753713,0.8871183,0.0002346686,0.00006656728,0.001960975,0.001729476,0.0003083027,0.001345368,0.008086622],"study_design_scores_gemma":[0.0006686863,0.000438911,0.1059221,0.001137636,0.8837641,0.0002741945,0.00008380054,0.002194511,0.001176104,0.001308723,0.002988307,0.00004282718],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3712761,0.5748956,0.03080941,0.002746572,0.001673565,0.0002573516,0.01536224,0.0007712256,0.002208058],"genre_scores_gemma":[0.9616119,0.02767644,0.005616735,0.0006473777,0.0003262913,0.0002687479,0.002869617,0.0001612282,0.0008217069],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01239687,"threshold_uncertainty_score":0.06556171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484522867505239,"score_gpt":0.2511275940820751,"score_spread":0.2162823654070227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}