{"id":"W3116583817","doi":"10.1093/brain/awaa401","title":"Targeted sequencing of Parkinson’s disease loci genes highlights <i>SYT11, FGF20</i> and other associations","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canadian Institutes of Health Research; Parkinson Canada; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Brookdale Foundation; National Center for Advancing Translational Sciences; Michael J. Fox Foundation for Parkinson's Research","keywords":"Genetics; Biology; Genetic association; Genome-wide association study; Gene; Exon; Allelic heterogeneity; Allele; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006827893,0.0001440367,0.0002624434,0.0000450506,0.00007118161,0.00001273741,0.0000476237,0.00005202982,0.0001232167],"category_scores_gemma":[0.0001451745,0.0001230943,0.00009142772,0.0001539817,0.00003439562,0.0000514975,0.00003146109,0.00005297133,0.00002376493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006905459,"about_ca_system_score_gemma":0.0001496132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006611376,"about_ca_topic_score_gemma":0.00001064797,"domain_scores_codex":[0.9990702,0.00005272792,0.0001926913,0.000277119,0.0002241978,0.0001830407],"domain_scores_gemma":[0.9992289,0.00005323574,0.0001033999,0.0001493174,0.00004591054,0.0004192233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001162634,0.001125235,0.6601207,0.0008840306,0.001986232,0.001168197,0.004528909,0.00005201041,0.2674764,0.01284041,0.03880453,0.009850749],"study_design_scores_gemma":[0.005781775,0.0003464706,0.3846195,0.0001378807,0.0008179753,0.000008604508,0.0002599959,0.001931078,0.03957801,0.001350243,0.5647209,0.0004475423],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829726,0.003042121,0.0003081532,0.01172123,0.00005963109,0.0004380502,0.0005702534,0.0001155581,0.0007724004],"genre_scores_gemma":[0.9932833,0.00006203106,0.0008746834,0.005202359,0.0001211507,0.00002353616,0.00009136557,0.00002801242,0.0003135513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5259163,"threshold_uncertainty_score":0.501964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978621349566569,"score_gpt":0.2595735306154256,"score_spread":0.2297873171197599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}