{"id":"W3116583817","doi":"10.1093/brain/awaa401","title":"Targeted sequencing of Parkinson’s disease loci genes highlights <i>SYT11, FGF20</i> and other associations","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canadian Institutes of Health Research; Parkinson Canada; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Brookdale Foundation; National Center for Advancing Translational Sciences; Michael J. Fox Foundation for Parkinson's Research","keywords":"Genetics; Biology; Genetic association; Genome-wide association study; Gene; Exon; Allelic heterogeneity; Allele; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008182684,0.0004572227,0.0007111104,0.0010003,0.000301574,0.0005391162,0.0002811881,0.0003598646,0.001348067],"category_scores_gemma":[0.001770788,0.0002248962,0.001169114,0.001427248,0.0002473614,0.0001199925,0.0003553813,0.0003278158,0.0002278171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178377,"about_ca_system_score_gemma":0.0005487974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004698232,"about_ca_topic_score_gemma":0.009240692,"domain_scores_codex":[0.9993761,0.0001463766,0.00007510478,0.0002328783,0.0001100453,0.00005947536],"domain_scores_gemma":[0.9990066,0.0005002975,0.000212584,0.00009478647,0.000107967,0.00007781353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003199025,0.0001200091,0.5274044,0.001519647,0.004712255,0.006047317,0.0008308859,0.005675186,0.3526452,0.001307254,0.002774558,0.09376417],"study_design_scores_gemma":[0.0003758105,0.0009041344,0.930286,0.0002225769,0.004030169,0.006080419,0.0002162858,0.004758655,0.03995485,0.001538924,0.01156978,0.0000624462],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749396,0.006109396,0.01198757,0.0002425094,0.00004913893,0.0001035444,0.005367601,0.0001150834,0.001085466],"genre_scores_gemma":[0.9836257,0.001975032,0.008862425,0.0002693362,0.00005139715,0.00008329837,0.004312063,0.00004549598,0.0007753514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004698232,"threshold_uncertainty_score":0.009341717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978621349566569,"score_gpt":0.2595735306154256,"score_spread":0.2297873171197599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}