{"id":"W3116613266","doi":"10.1002/med.21774","title":"Drug design targeting active posttranslational modification protein isoforms","year":2020,"lang":"en","type":"review","venue":"Medicinal Research Reviews","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"K. C. Wong Education Foundation; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China; Taishan Scholar Foundation of Shandong Province","keywords":"Drug; Gene isoform; Pharmacology; Chemistry; Posttranslational modification; Drug discovery; Computational biology; Medicine; Biology; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003141632,0.0004823867,0.0005589582,0.000338149,0.0002140597,0.000627064,0.0005262245,0.0006193341,0.001661865],"category_scores_gemma":[0.0002165226,0.0002434925,0.0005370769,0.0002986336,0.0003276771,0.0006904822,0.0005859897,0.001009197,0.0005954017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004861676,"about_ca_system_score_gemma":0.0005034786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639523,"about_ca_topic_score_gemma":0.0005559982,"domain_scores_codex":[0.999856,0.00002308614,0.00001151428,0.00004257698,0.00003716143,0.0000295673],"domain_scores_gemma":[0.9999337,0.000008890357,0.00002186935,0.000008069627,0.0000143192,0.00001323135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009591162,0.0003535917,0.001903859,0.001878581,0.0001659174,0.001237021,0.000114873,0.0240591,0.7009966,0.06110746,0.006256783,0.2009672],"study_design_scores_gemma":[0.0006273011,0.00414664,0.001744917,0.0001985553,0.0003278797,0.002568473,0.0001023668,0.06529687,0.6371855,0.02117403,0.2665035,0.0001241353],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4415054,0.113816,0.382048,0.005626936,0.001541069,0.001021682,0.001828415,0.001303583,0.05130906],"genre_scores_gemma":[0.8659683,0.04390653,0.07353895,0.001755334,0.0002005277,0.0004444461,0.001046404,0.00009211293,0.01304731],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001661865,"threshold_uncertainty_score":0.005559504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2992623259318687,"score_gpt":0.4572428993680607,"score_spread":0.157980573436192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}