{"id":"W3116613266","doi":"10.1002/med.21774","title":"Drug design targeting active posttranslational modification protein isoforms","year":2020,"lang":"en","type":"review","venue":"Medicinal Research Reviews","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"K. C. Wong Education Foundation; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China; Taishan Scholar Foundation of Shandong Province","keywords":"Drug; Gene isoform; Pharmacology; Chemistry; Posttranslational modification; Drug discovery; Computational biology; Medicine; Biology; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006317621,0.0004770122,0.001352984,0.0001865143,0.0002841317,0.00005088731,0.0007796308,0.0003581858,0.0001849101],"category_scores_gemma":[0.003211681,0.0003312178,0.0004863659,0.0005840534,0.0002250494,0.000009923038,0.0001895272,0.001280695,0.0005868005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001182427,"about_ca_system_score_gemma":0.001295103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001441999,"about_ca_topic_score_gemma":0.000002547819,"domain_scores_codex":[0.993559,0.002960986,0.0009724312,0.0009018259,0.0009429348,0.0006628285],"domain_scores_gemma":[0.998212,0.0001702063,0.0004031556,0.0005408088,0.0003144917,0.0003593807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005513216,0.00003540325,1.36348e-7,0.00913306,0.0000608644,0.00001082022,0.00008866977,1.946381e-7,0.002281392,0.00008508348,0.01090118,0.9773481],"study_design_scores_gemma":[0.0001531288,0.0003413854,2.542223e-7,0.008061737,0.0000808266,0.0000199336,0.00002721749,0.0000145603,0.00199203,0.0001242952,0.9888741,0.0003105741],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003066235,0.9875053,0.003979299,0.0003436127,0.00006662936,0.006627763,0.00006351325,0.00001694373,0.001393858],"genre_scores_gemma":[0.00002124513,0.9907471,0.002948967,0.0000637499,0.001245796,0.002487194,0.001320564,0.00007689421,0.001088512],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9779729,"threshold_uncertainty_score":0.999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2992623259318687,"score_gpt":0.4572428993680607,"score_spread":0.157980573436192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}