{"id":"W3116694340","doi":"10.1124/molpharm.120.000108","title":"Short-Term Acyl-CoA:Cholesterol Acyltransferase Inhibition, Combined with Apoprotein A1 Overexpression, Promotes Atherosclerosis Inflammation Resolution in Mice","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; U.S. Department of Agriculture; NYU Grossman School of Medicine; York University; American Heart Association","keywords":"Inflammation; Lecithin—cholesterol acyltransferase; Chemistry; Cholesterol; Acyltransferase; Acyl-CoA; Sterol O-acyltransferase; Biochemistry; Apolipoprotein B; Internal medicine; Medicine; Lipoprotein; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004028752,0.001053215,0.00084423,0.001131488,0.0004106537,0.0007308077,0.0004941433,0.0009240373,0.001956758],"category_scores_gemma":[0.0002191594,0.0005236382,0.0008229053,0.0004923609,0.0008900745,0.0006410116,0.0003714669,0.003208461,0.0008543236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005570868,"about_ca_system_score_gemma":0.0006233209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008997897,"about_ca_topic_score_gemma":0.001513303,"domain_scores_codex":[0.9994779,0.0000712762,0.00005677066,0.0001120837,0.00009369796,0.0001884113],"domain_scores_gemma":[0.9992517,0.00005328213,0.0002147671,0.00006583481,0.00004150835,0.0003729609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003012046,0.0004222987,0.0001630909,0.00005945344,0.00002062381,0.00009976596,0.00002982974,0.00008386975,0.9943514,0.0001858706,0.0001693429,0.001402416],"study_design_scores_gemma":[0.0003394976,0.002766344,0.003879157,0.00001971371,0.00009043952,0.0002624114,0.0001052293,0.001016394,0.988972,0.0002039805,0.002322357,0.00002241079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907798,0.002260683,0.002945347,0.0007153032,0.0002578715,0.00004995426,0.001136574,0.0003944717,0.001460031],"genre_scores_gemma":[0.9844593,0.001937726,0.003156007,0.0003439529,0.0001142919,0.0001482967,0.001284987,0.0001247017,0.008430743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001956758,"threshold_uncertainty_score":0.006546021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782131587987183,"score_gpt":0.2653855391127533,"score_spread":0.2475642232328815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}