{"id":"W3116851193","doi":"10.1186/s12859-020-03877-9","title":"Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study","year":2020,"lang":"en","type":"article","venue":"BMC Bioinformatics","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; Fundamental Research Funds for the Central Universities; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; H. Lundbeck A/S; IXICO; Natural Science Foundation of Heilongjiang Province; Harbin Engineering University; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Pennsylvania; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Neuroimaging; Connectome; Functional magnetic resonance imaging; Neuroscience; Discriminative model; Diffusion MRI; Imaging genetics; Artificial intelligence; Computer science; Computational biology; Medicine; Machine learning; Magnetic resonance imaging; Disease; Biology; Functional connectivity; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002003677,0.0004513681,0.0003890064,0.0009319565,0.0003198482,0.000449358,0.0004519896,0.000489848,0.001534724],"category_scores_gemma":[0.006374527,0.000151203,0.0007590222,0.0005424654,0.0007849049,0.000683994,0.0009493211,0.000619675,0.00009781945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003122316,"about_ca_system_score_gemma":0.0002905944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002099433,"about_ca_topic_score_gemma":0.00187823,"domain_scores_codex":[0.9994588,0.0002539177,0.00002153826,0.0001597956,0.00006223346,0.00004363722],"domain_scores_gemma":[0.995261,0.003035723,0.0007951875,0.0005302854,0.0001682644,0.000209626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00524452,0.001063823,0.5923249,0.0003144858,0.003702116,0.003259692,0.001332594,0.08788679,0.1050902,0.009149541,0.001417795,0.1892136],"study_design_scores_gemma":[0.0001322957,0.000917458,0.5182277,0.00004170414,0.001264602,0.001890116,0.0003659394,0.4413339,0.01495677,0.01993238,0.0008620233,0.00007510806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678027,0.0001658043,0.0313539,0.0001634158,0.00000496985,0.00001520486,0.0001455021,0.00004617944,0.0003022432],"genre_scores_gemma":[0.9948629,0.00005111809,0.004789006,0.00002095966,0.000008593112,0.00001105581,0.0001347572,0.0000138221,0.0001078042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002099433,"threshold_uncertainty_score":0.01059663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0443465359365428,"score_gpt":0.2805188398877967,"score_spread":0.2361723039512539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}