{"id":"W3116981118","doi":"10.1016/j.semcancer.2020.12.017","title":"Senescence: A program in the road to cell elimination and cancer","year":2020,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Cancer Society Research Institute","keywords":"Senescence; Biology; Cancer cell; Nuclear lamina; Cancer; Cell biology; Epigenetics; Cancer research; Polyploid; Suppressor; Cell growth; Cell; Immunology; Genetics; Ploidy; Nuclear protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000347868,0.0004140289,0.001440411,0.0003274105,0.00004140081,0.00001861418,0.0003155758,0.0004601846,0.00006403081],"category_scores_gemma":[0.0001024968,0.0002746084,0.0001228743,0.001146757,0.0001646691,0.00002871954,0.000102458,0.0007152108,0.00001680989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740403,"about_ca_system_score_gemma":0.0006492673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511428,"about_ca_topic_score_gemma":0.001067608,"domain_scores_codex":[0.9977338,0.0002826409,0.000577573,0.0007544701,0.0001657679,0.0004857972],"domain_scores_gemma":[0.9991191,0.0001700662,0.0001939502,0.0003322558,0.00005101052,0.0001335854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004254688,0.0001040761,0.001999595,0.00489906,0.00001875704,0.000100203,0.00117849,2.773231e-7,0.00003399702,0.0000132071,0.001267343,0.9903424],"study_design_scores_gemma":[0.0003455106,0.0004484119,0.001339164,0.01117841,0.0001886345,0.00005527602,0.0002470894,0.00001296132,0.00001638304,0.00000947552,0.9858661,0.0002925757],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00119945,0.993142,0.000002724583,0.002183584,0.0003984055,0.002612505,0.00007653573,0.00003629826,0.0003484717],"genre_scores_gemma":[0.001354152,0.9941252,0.0002746852,0.00107092,0.0003738105,0.002422248,0.00009084498,0.00003751985,0.0002506101],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9900499,"threshold_uncertainty_score":0.9999706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05096501971235406,"score_gpt":0.4143271311579862,"score_spread":0.3633621114456321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}