{"id":"W3117015724","doi":"10.1139/cjpp-2020-0558","title":"Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Tumor necrosis factor alpha; Signal transduction; Cell adhesion molecule; Cell biology; Inflammation; NF-κB; Nitric oxide; Chemistry; Endothelial activation; ICAM-1; IκBα; Proinflammatory cytokine; Intercellular Adhesion Molecule-1; IκB kinase; Nitric oxide synthase; VCAM-1; Cell adhesion; Biology; Immunology; Biochemistry; Cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036876,0.0003929171,0.0004743413,0.0002164701,0.0001160743,0.0001621234,0.0002874062,0.0002524278,0.0008170747],"category_scores_gemma":[0.0001627968,0.0001117434,0.0003198988,0.0001441769,0.0001775861,0.0001937951,0.0001339246,0.0006378155,0.0001890159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232577,"about_ca_system_score_gemma":0.000180594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092009,"about_ca_topic_score_gemma":0.0004001029,"domain_scores_codex":[0.9999132,0.00002379452,0.00001378502,0.00001115372,0.00001876131,0.00001927983],"domain_scores_gemma":[0.9999391,0.000008538192,0.00001925047,0.000007556055,0.00001137533,0.00001432479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002333029,0.0003804267,0.0002686423,0.0004975484,0.00005674667,0.0001403562,0.00003132856,0.0002945783,0.9843295,0.0001874447,0.0002564738,0.01122399],"study_design_scores_gemma":[0.000295914,0.003153719,0.004181222,0.00003888271,0.000120617,0.0006645786,0.00003624508,0.001946483,0.9796392,0.0001603122,0.009749761,0.00001305873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684576,0.02170106,0.005279969,0.000279695,0.0002172203,0.00008401964,0.0003538186,0.0002892424,0.00333736],"genre_scores_gemma":[0.9819118,0.01115671,0.003410871,0.0001626272,0.00008723047,0.0001334199,0.0006689641,0.00002802096,0.002440379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008170747,"threshold_uncertainty_score":0.00273335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0269582905439812,"score_gpt":0.2504631540124132,"score_spread":0.223504863468432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}