{"id":"W3117078967","doi":"10.3390/toxins12120807","title":"Tolerability and Efficacy of Customized IncobotulinumtoxinA Injections for Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Study","year":2020,"lang":"en","type":"article","venue":"Toxins","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; West Park Healthcare Centre; Dalhousie University; University Health Network; University of Toronto; Lawson Health Research Institute","funders":"Allergan; Teva Pharmaceutical Industries; Ipsen; Boston Scientific Corporation; Merz Pharmaceuticals; Medtronic","keywords":"Placebo; Medicine; Tolerability; Physical medicine and rehabilitation; Physical therapy; Randomized controlled trial; Essential tremor; Upper limb; Anesthesia; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003691897,0.0002196846,0.001644404,0.00007004623,0.0001038669,0.00001756701,0.00006979679,0.00008927727,0.0001106983],"category_scores_gemma":[0.0008025432,0.0001475849,0.0004118979,0.000185606,0.0001561183,0.00004480974,0.00005471022,0.0001549829,0.000007030679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001738789,"about_ca_system_score_gemma":0.00006376324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006529818,"about_ca_topic_score_gemma":0.00002769882,"domain_scores_codex":[0.9983479,0.000200205,0.0006184272,0.0004357967,0.0001918046,0.0002058818],"domain_scores_gemma":[0.998444,0.0008624916,0.0001782949,0.0002229509,0.0000904443,0.0002018792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.991218,0.003917982,0.001638738,0.00005561156,0.0007339212,0.000014181,0.0008362146,0.00003697081,0.0005760023,0.00009267707,0.0001037863,0.0007759458],"study_design_scores_gemma":[0.9917307,0.002659552,0.001104814,0.000008743194,0.001610642,0.000003166605,0.0002236665,0.001906433,0.0003619694,0.0002416161,0.00003489935,0.000113776],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840098,0.0001211796,0.0006615939,0.002515645,0.00008115028,0.0115969,0.00001808806,0.00008040637,0.000915248],"genre_scores_gemma":[0.9982402,0.00002065705,0.0002725208,0.0004442434,0.00009451881,0.0007502431,0.00001530756,0.00001940753,0.0001429358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01423038,"threshold_uncertainty_score":0.6018339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04121911364977576,"score_gpt":0.3245036425363338,"score_spread":0.2832845288865581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}