{"id":"W3117171794","doi":"10.1016/j.chemphyslip.2020.105032","title":"Cationic lipids for gene delivery: many players, one goal","year":2021,"lang":"en","type":"review","venue":"Chemistry and Physics of Lipids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Politecnico di Milano","keywords":"Cationic polymerization; Chemistry; Linker; Gene delivery; Transfection; Nucleic acid; Supramolecular chemistry; Computational biology; Nanotechnology; Combinatorial chemistry; Gene; Biochemistry; Computer science; Organic chemistry; Molecule; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118044,0.0009178817,0.001254163,0.001282651,0.0003455908,0.001616301,0.001145134,0.001871237,0.002725365],"category_scores_gemma":[0.000749969,0.0002525633,0.0004023309,0.001542001,0.001006012,0.00259882,0.001191383,0.003306188,0.001788918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009545566,"about_ca_system_score_gemma":0.001241818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008238099,"about_ca_topic_score_gemma":0.001219441,"domain_scores_codex":[0.9997608,0.0000484292,0.00001938477,0.00003610349,0.0001013834,0.00003378353],"domain_scores_gemma":[0.9996852,0.0001626032,0.00003020637,0.00001202753,0.00006823881,0.00004175653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001695587,0.0001203705,0.00012994,0.0143083,0.0000701763,0.0003450024,0.0001066257,0.0007093252,0.02072228,0.04485417,0.05892475,0.8595394],"study_design_scores_gemma":[0.00002407827,0.00008628,0.0001399166,0.00130194,0.00004050837,0.0006145026,0.00004399986,0.0001271481,0.003397219,0.005816265,0.9883839,0.00002430737],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001533478,0.9958966,0.0007335573,0.001423499,0.0004473561,0.000005081564,0.00001475096,0.00001385126,0.001311969],"genre_scores_gemma":[0.001072692,0.9964423,0.0005195208,0.0005623327,0.0002527299,0.00001106577,0.00001876664,0.000003996281,0.001116564],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002725365,"threshold_uncertainty_score":0.009117246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03030432388784079,"score_gpt":0.2927022654914481,"score_spread":0.2623979416036074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}