{"id":"W3117207610","doi":"10.1101/2020.12.23.423975","title":"FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Sinai Health System; Montreal Clinical Research Institute; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Wayne State University","keywords":"Somatic hypermutation; Cytidine deaminase; Immunoglobulin class switching; Base excision repair; DNA repair; Uracil-DNA glycosylase; DNA mismatch repair; DNA glycosylase; Chemistry; Cell biology; DNA; Biology; Molecular biology; Antibody; Genetics; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720263,0.0005525777,0.0004714491,0.0004206011,0.0002191506,0.0003304327,0.0004830838,0.0006217746,0.002538269],"category_scores_gemma":[0.0001661717,0.0001946167,0.0003122197,0.0002002592,0.0002605377,0.0001933805,0.0002804181,0.0007115232,0.0006652406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003936318,"about_ca_system_score_gemma":0.0002106483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008901734,"about_ca_topic_score_gemma":0.001537941,"domain_scores_codex":[0.9998022,0.00002980947,0.00002065377,0.00004547578,0.00004796654,0.00005398205],"domain_scores_gemma":[0.9998417,0.00002614431,0.00004820084,0.00001681812,0.00001492458,0.00005221972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002519987,0.00004862767,0.0001274737,0.0000586537,0.000008977371,0.00006444774,0.000009509534,0.0001144922,0.997329,0.00007955919,0.0001183826,0.00178872],"study_design_scores_gemma":[0.00006125821,0.0007707039,0.002168261,0.000011899,0.00002651842,0.0002534579,0.00001984017,0.001053728,0.9908771,0.00003689721,0.004713144,0.000007007154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872769,0.004981607,0.003025549,0.000350825,0.0001223844,0.00009042392,0.0009980582,0.0005066483,0.002647683],"genre_scores_gemma":[0.9938645,0.001191683,0.001775263,0.0001344785,0.00001987996,0.00006146797,0.0006659273,0.00004552039,0.002241304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538269,"threshold_uncertainty_score":0.008491337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009685964324174316,"score_gpt":0.2336159118000916,"score_spread":0.2239299474759173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}