{"id":"W3117279292","doi":"10.1097/shk.0000000000001704","title":"Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands","year":2020,"lang":"en","type":"article","venue":"Shock","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Innate immune system; Pattern recognition receptor; Signal transducing adaptor protein; Receptor; Signal transduction; Cell biology; Pathogen-associated molecular pattern; Biology; Toll-like receptor; Transcription factor; Intracellular; Function (biology); Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917397,0.0004812044,0.0003397295,0.0006372678,0.0001726259,0.0008226858,0.0002268099,0.0005623579,0.001487541],"category_scores_gemma":[0.0001316197,0.000103944,0.0001738078,0.0005864064,0.0003693973,0.0006865672,0.0003209047,0.0006382643,0.0005431639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005419808,"about_ca_system_score_gemma":0.0003338579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003129749,"about_ca_topic_score_gemma":0.0004352882,"domain_scores_codex":[0.9999105,0.00002309453,0.000008482984,0.00001541244,0.00002782429,0.00001473923],"domain_scores_gemma":[0.9999342,0.000021588,0.00001844511,0.000001603797,0.00001233079,0.00001188125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009729763,0.0001929049,0.002416758,0.01217854,0.0001627454,0.002808105,0.0003829355,0.003034586,0.2638577,0.06476585,0.02295131,0.6262755],"study_design_scores_gemma":[0.00004245956,0.0006087292,0.01128492,0.001548406,0.0001274664,0.005907826,0.0004972908,0.001909402,0.0459473,0.0346215,0.8974362,0.00006850826],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01267271,0.9765815,0.002067195,0.001823922,0.0005375084,0.00001672234,0.00007367995,0.00003813865,0.006188598],"genre_scores_gemma":[0.06138941,0.9230319,0.001961306,0.0008941473,0.001293134,0.00003568065,0.0002148152,0.000007866544,0.01117176],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001487541,"threshold_uncertainty_score":0.004976332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005349217356883,"score_gpt":0.2061354603487342,"score_spread":0.1960819681751654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}