{"id":"W3117279292","doi":"10.1097/shk.0000000000001704","title":"Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands","year":2020,"lang":"en","type":"article","venue":"Shock","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Innate immune system; Pattern recognition receptor; Signal transducing adaptor protein; Receptor; Signal transduction; Cell biology; Pathogen-associated molecular pattern; Biology; Toll-like receptor; Transcription factor; Intracellular; Function (biology); Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457996,0.0001146833,0.0001847985,0.0000266127,0.00012757,0.00001734026,0.00008881267,0.0002694626,0.0002829134],"category_scores_gemma":[0.0001408666,0.0001068366,0.00004922343,0.0001183523,0.00006759498,0.0000588951,0.00006463183,0.0002331711,0.0001618099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000193143,"about_ca_system_score_gemma":0.00002541497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007335712,"about_ca_topic_score_gemma":6.881413e-7,"domain_scores_codex":[0.9992732,0.00008320689,0.0002042418,0.000190955,0.00002249443,0.0002259304],"domain_scores_gemma":[0.9996936,0.00009425845,0.00006663964,0.00008706217,0.00003155292,0.00002689402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760534,0.00001755879,0.0007303244,0.00000779251,0.0001289384,0.000003074795,0.0004876261,0.0000218616,0.9469174,0.0000484015,0.04803947,0.003321517],"study_design_scores_gemma":[0.001571066,0.0002836999,0.0008940353,0.00005800583,0.00006663801,0.00002016774,0.000294783,0.0007598483,0.8981016,0.00004850666,0.09756552,0.0003360767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992171,0.005007701,0.0004493645,0.001323461,0.0005481681,0.0001147351,0.000002546266,0.0001193073,0.0002636948],"genre_scores_gemma":[0.997991,0.0001732286,0.00003129032,0.0006570156,0.00007645312,0.000003194034,0.0002018152,0.00001254275,0.0008535052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04952605,"threshold_uncertainty_score":0.4356669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005349217356883,"score_gpt":0.2061354603487342,"score_spread":0.1960819681751654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}