{"id":"W3117444659","doi":"10.1016/j.nicl.2020.102540","title":"Disease-related cortical thinning in presymptomatic granulin mutation carriers","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Toronto Western Hospital; Montreal Neurological Institute and Hospital; University of Toronto; Western University; McGill University Health Centre; Sunnybrook Health Science Centre","funders":"NIHR Cambridge Biomedical Research Centre; UCLH Biomedical Research Centre; Instituto de Salud Carlos III; Medical Research Council; Stockholm läns landsting; Stichting Dioraphte; Stockholms Läns Landsting; Alzheimer’s Research UK; FONDATION ALZHEIMER; Weston Brain Institute; ZonMw; Brain Foundation; Wellcome Trust; University College London; Wolfson Foundation; Brain Research Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Alzheimer's Society; National Institute for Health and Care Research; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Canadian Institutes of Health Research; Fundació la Marató de TV3; Horizon 2020; UK Dementia Research Institute; Ontario Brain Institute; Association for Frontotemporal Degeneration","keywords":"Frontotemporal dementia; Neuroimaging; Disease; Dementia; Medicine; Age of onset; Neuroscience; Psychology; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005604605,0.0001680324,0.0004662681,0.00006516386,0.00005881776,0.00003716351,0.0001707127,0.0001486137,0.0004281044],"category_scores_gemma":[0.00828541,0.0001434992,0.0002044361,0.0004321805,0.0003083245,0.0001373861,0.0001215641,0.001362826,0.0003350938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004375741,"about_ca_system_score_gemma":0.0001914353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001262067,"about_ca_topic_score_gemma":0.000001315023,"domain_scores_codex":[0.9968197,0.0005822727,0.0010106,0.0006047257,0.0005834034,0.0003993236],"domain_scores_gemma":[0.9978518,0.0006779053,0.00009269876,0.00032391,0.00007570683,0.0009780157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003713364,0.000891277,0.9563805,0.0003988127,0.0001175679,0.01030677,0.001315742,0.000323554,0.009408869,0.0002478138,0.004943375,0.01195238],"study_design_scores_gemma":[0.003199928,0.0005745004,0.9036627,0.00009638721,0.00006790847,0.00001692672,0.00002744216,0.09181233,0.00002133484,0.0001413204,0.000258568,0.0001206427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779819,0.00006496067,0.0001108879,0.02032339,0.0001407222,0.0006427969,0.000005664436,0.0001693472,0.0005603782],"genre_scores_gemma":[0.9944236,0.00004830508,0.0003789656,0.004778601,0.0001793579,0.00001981809,0.00003074241,0.00004295583,0.00009767448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09148877,"threshold_uncertainty_score":0.9919009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09602940029195389,"score_gpt":0.3939617860206334,"score_spread":0.2979323857286795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}