{"id":"W3117475697","doi":"10.1002/jev2.12050","title":"Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus","year":2020,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Fondation ARC pour la Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; CNIB; Institut National Du Cancer; Sidaction; Association pour la Recherche sur le Cancer; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Infectivity; Extracellular vesicles; Extracellular; TMPRSS2; Lipid bilayer fusion; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Fusion protein; Virus; HEK 293 cells; Coronavirus; Spike Protein; Priming (agriculture); Virology; Viral entry; Chemistry; Cell biology; Biology; Receptor; Coronavirus disease 2019 (COVID-19); Biochemistry; Recombinant DNA; Gene; Medicine; Viral replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001512764,0.0007109154,0.0007948034,0.0001826599,0.0003238895,0.0002449906,0.0008509253,0.0004657066,0.00007313532],"category_scores_gemma":[0.0008010915,0.0007192221,0.0007397582,0.0003938414,0.0002883037,0.0001059768,0.0002916818,0.000801876,0.00005441006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001166393,"about_ca_system_score_gemma":0.0003523671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003090526,"about_ca_topic_score_gemma":0.00001221055,"domain_scores_codex":[0.9949425,0.0005719178,0.001821501,0.000871573,0.0009211697,0.0008712735],"domain_scores_gemma":[0.9964983,0.00007066366,0.001695822,0.0006571878,0.0004301173,0.000647834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001213154,0.0006921676,0.001280115,0.0001366501,0.0003163579,0.0003613019,0.000435482,0.0005740145,0.9853591,0.0002385897,0.003284757,0.006108306],"study_design_scores_gemma":[0.002111092,0.002604415,0.0002848999,0.0002030202,0.0002293045,0.000173005,0.0003555197,0.0007603316,0.9234224,0.0001647629,0.06895454,0.0007367273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9179763,0.05162638,0.0284351,0.0006673329,0.0003139931,0.0007333953,0.00004357476,0.00006320593,0.000140723],"genre_scores_gemma":[0.9942317,0.0004431077,0.003179656,0.0003554221,0.00114884,0.0000290958,0.00008245779,0.0001714742,0.0003582304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07625541,"threshold_uncertainty_score":0.9995259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849683852111214,"score_gpt":0.2622909881650224,"score_spread":0.2437941496439102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}