{"id":"W3117937028","doi":"10.21203/rs.3.rs-18107/v1","title":"Inhaled granulocyte-macrophage colony stimulating factor for mild-to-moderate autoimmune pulmonary alveolar proteinosis - a phase II randomized study for 6 months and follow-up to 24 months","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Key Research and Development Program of China; Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Granulocyte macrophage colony-stimulating factor; Medicine; Pulmonary alveolar proteinosis; Granulocyte; Alveolar macrophage; Immunology; Randomized controlled trial; Pulmonary alveolus; Macrophage; Granulocyte macrophage colony-stimulating factor receptor; Internal medicine; Gastroenterology; Respiratory disease; Lung; In vitro; Cytokine; Macrophage colony-stimulating factor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502822,0.001768023,0.004309723,0.0005189028,0.0005205932,0.001130555,0.001135835,0.001945025,0.005814918],"category_scores_gemma":[0.0009457894,0.0005920973,0.002217987,0.0004403833,0.001656447,0.0009698841,0.0004136983,0.002603761,0.001251395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007259173,"about_ca_system_score_gemma":0.001225704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428364,"about_ca_topic_score_gemma":0.002621928,"domain_scores_codex":[0.9994574,0.0002105818,0.00002461926,0.0001036135,0.00004356722,0.0001600985],"domain_scores_gemma":[0.9992467,0.0001649718,0.0001185941,0.00009404273,0.00005082678,0.0003247479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9713707,0.01023229,0.0004931942,0.0002701957,0.0005869127,0.00003174556,0.00002469321,0.0002688627,0.00308418,0.00007097486,0.0005325647,0.01303363],"study_design_scores_gemma":[0.8907353,0.1059343,0.001997601,0.0000155138,0.0002985506,0.00002161298,0.00001760202,0.00018182,0.000341455,0.00009322102,0.0003516991,0.00001118948],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877796,0.004278207,0.0008190006,0.0004948953,0.0005569666,0.002959548,0.00115995,0.0001620238,0.001789816],"genre_scores_gemma":[0.9808075,0.002986385,0.001724742,0.001402348,0.0007639428,0.004455799,0.001634493,0.00005056772,0.006174128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005814918,"threshold_uncertainty_score":0.01945281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1458621670796406,"score_gpt":0.4712284997800488,"score_spread":0.3253663327004082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}