{"id":"W3117944008","doi":"10.1371/journal.ppat.1009097","title":"Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Public Health Agency; Public Health Agency of Canada; Manitoba Health Research Council","keywords":"Medroxyprogesterone acetate; Lactobacillus; Microbiome; Context (archaeology); Bacterial vaginosis; Medicine; Physiology; Hormonal contraception; Vagina; Immunology; Population; Hormone; Gynecology; Obstetrics; Internal medicine; Family planning; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006251917,0.000186372,0.0002731549,0.0002575247,0.000224542,0.0006139524,0.0001118076,0.0002711443,0.003803706],"category_scores_gemma":[0.002453029,0.0001749129,0.000308794,0.0004786033,0.0001593211,0.0002499717,0.0003792793,0.0004103223,0.0001991503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001484113,"about_ca_system_score_gemma":0.0003160278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104451,"about_ca_topic_score_gemma":0.001596152,"domain_scores_codex":[0.9994911,0.0002650435,0.00002510673,0.00006283652,0.00006549348,0.00009035781],"domain_scores_gemma":[0.9993008,0.0002358608,0.0002980611,0.00004360724,0.00003450755,0.00008711218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004433098,0.000195009,0.9353219,0.0003006412,0.000775565,0.0002078025,0.0001738172,0.000147911,0.004486388,0.0001804211,0.000568399,0.05320908],"study_design_scores_gemma":[0.00004894832,0.0008236601,0.9955394,0.00005270786,0.000286675,0.000417771,0.0001720553,0.0003012475,0.0006350488,0.000179118,0.001536678,0.000006672687],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840178,0.01293459,0.0002914355,0.0002598383,0.00003010262,0.00002335112,0.0005332768,0.000007985885,0.001901518],"genre_scores_gemma":[0.9976774,0.001371533,0.0001819812,0.00006453724,0.00002331773,0.00001349607,0.0001782835,0.000002692991,0.0004867916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003803706,"threshold_uncertainty_score":0.01272464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998039124175525,"score_gpt":0.2429929960720334,"score_spread":0.2230126048302782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}