{"id":"W3118032135","doi":"10.1371/journal.pone.0224953","title":"The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; J.P. Bickell Foundation","keywords":"Spliceosome; Activating transcription factor; Gene knockdown; Biology; RNA splicing; Cell biology; ATF3; Molecular biology; Transcription factor; Apoptosis; Genetics; Gene expression; Gene; RNA; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174099,0.0002779875,0.0002304571,0.0002210818,0.00008883128,0.0001473577,0.0001712081,0.0002784966,0.0007916964],"category_scores_gemma":[0.0000668407,0.00009774355,0.0002932819,0.0001113267,0.0001503819,0.0001035728,0.0001027711,0.0005303918,0.0002104733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406319,"about_ca_system_score_gemma":0.0001603543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005498229,"about_ca_topic_score_gemma":0.0008321326,"domain_scores_codex":[0.9998858,0.00002131508,0.00001376267,0.0000205485,0.00003583627,0.00002274169],"domain_scores_gemma":[0.9999394,0.00001140629,0.00001832408,0.000008565925,0.000007999456,0.00001429802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139838,0.0000316525,0.00007020994,0.00002375957,0.000005159688,0.00003215102,0.000005807127,0.00003183319,0.9985178,0.00004183477,0.00003083438,0.001069147],"study_design_scores_gemma":[0.00001528219,0.0003710663,0.00127994,0.000003126792,0.000006699452,0.0001219123,0.000008715819,0.0002367038,0.9969841,0.00002758275,0.0009429402,0.000001897315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885629,0.003112583,0.004668302,0.0002001314,0.0000672745,0.00007754776,0.0004936151,0.0001355394,0.002682108],"genre_scores_gemma":[0.9905379,0.001872581,0.004236502,0.0001594038,0.00001483356,0.00007421403,0.0006742665,0.00002303907,0.002407191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007916964,"threshold_uncertainty_score":0.002648473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329946758639274,"score_gpt":0.2299265437475972,"score_spread":0.1969318678836698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}