{"id":"W3118088258","doi":"10.3324/haematol.2020.271619","title":"Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis","year":2020,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal; Université Laval; Centre hospitalier de l'Université Laval; Hôpital de l'Enfant-Jésus; Institute for Research in Immunology and Cancer","funders":"Université de Montréal; CHU Sainte-Justine Foundation; Molson Foundation","keywords":"Biology; Epigenetics; Epigenome; Genetics; Cancer research; DNA methylation; Chromatin; Regulation of gene expression; Epigenomics; Transcription factor; Demethylase; Histone; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002031124,0.0003513276,0.0008426815,0.0002625174,0.0001748654,0.00002321798,0.0004284036,0.0003115651,0.0002856668],"category_scores_gemma":[0.000215667,0.000294766,0.0001419618,0.0006067625,0.0001163093,0.00008156533,0.0003458576,0.000536248,0.0002835862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000550928,"about_ca_system_score_gemma":0.0002459546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001500287,"about_ca_topic_score_gemma":0.00008069009,"domain_scores_codex":[0.9972342,0.0001350458,0.0004843519,0.0007611426,0.0005590085,0.0008262416],"domain_scores_gemma":[0.998746,0.00006588062,0.0001186489,0.0005097158,0.00009019484,0.0004695972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002131984,0.000656948,0.2484159,0.002200494,0.0004314885,0.01203646,0.006059415,0.001989099,0.7166159,0.002640088,0.00504036,0.001781831],"study_design_scores_gemma":[0.01291064,0.001809185,0.4316602,0.0005698949,0.0002578333,0.0009186616,0.0004316879,0.02676081,0.520709,0.001272313,0.001204594,0.001495132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877459,0.0004319661,0.0001424135,0.008736578,0.00003160313,0.0007976515,0.00001008901,0.0002364887,0.001867356],"genre_scores_gemma":[0.9958345,0.000282623,0.001263828,0.001156683,0.0001278287,0.0001572452,0.00002243538,0.00006570974,0.001089132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1959068,"threshold_uncertainty_score":0.9999505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05493851507936829,"score_gpt":0.2996878199912756,"score_spread":0.2447493049119073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}