{"id":"W3118147665","doi":"10.1158/1078-0432.ccr-20-3313","title":"Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"National Cancer Institute; Instituto de Salud Carlos III; Gobierno de Navarra; Universidad de Navarra; European Commission; U.S. Department of Defense","keywords":"Oncolytic virus; Proinflammatory cytokine; Oncolytic adenovirus; Immune system; Biology; Cancer research; Medicine; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002354443,0.0003728131,0.00026872,0.0002222608,0.00008907829,0.000294929,0.0001447951,0.0001550996,0.0006837995],"category_scores_gemma":[0.00009589946,0.00009133892,0.0002088383,0.000121144,0.0002283551,0.000192279,0.0001031389,0.0006111172,0.0002295419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002543108,"about_ca_system_score_gemma":0.0002949484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003465138,"about_ca_topic_score_gemma":0.0005064548,"domain_scores_codex":[0.9998477,0.00002409683,0.00001910019,0.00004044629,0.00003726922,0.00003137016],"domain_scores_gemma":[0.9999018,0.00001257825,0.00003289897,0.00001318079,0.00001311372,0.00002647389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003966228,0.0001214019,0.0003275645,0.00005153737,0.000006819097,0.00003607347,0.00001501197,0.0001501894,0.9973732,0.00003362645,0.00003821365,0.001449706],"study_design_scores_gemma":[0.00003637863,0.001979655,0.003099045,0.000008119036,0.00002700344,0.0002480851,0.00003809871,0.001257962,0.9924102,0.00002470061,0.0008670756,0.000003717676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968773,0.0008018689,0.001430703,0.00003769438,0.00002314898,0.00003149784,0.0002985831,0.00005517325,0.0004439887],"genre_scores_gemma":[0.9957711,0.0006302767,0.001692069,0.00002331023,0.000006704312,0.0000420818,0.0003917762,0.00001239016,0.001430333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006837995,"threshold_uncertainty_score":0.002287567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1861770248592693,"score_gpt":0.4505054595599348,"score_spread":0.2643284347006655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}