{"id":"W3118147665","doi":"10.1158/1078-0432.ccr-20-3313","title":"Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"National Cancer Institute; Instituto de Salud Carlos III; Gobierno de Navarra; Universidad de Navarra; European Commission; U.S. Department of Defense","keywords":"Oncolytic virus; Proinflammatory cytokine; Oncolytic adenovirus; Immune system; Biology; Cancer research; Medicine; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003761872,0.0001874637,0.0004624036,0.0001062645,0.0001156186,0.00004308563,0.000396061,0.0002709859,0.00005013855],"category_scores_gemma":[0.0008157638,0.0001740021,0.00007226879,0.0002785932,0.0005639333,0.00002326331,0.0007226624,0.0006261935,0.000003228388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004101617,"about_ca_system_score_gemma":0.0007435909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671638,"about_ca_topic_score_gemma":0.002644464,"domain_scores_codex":[0.9963756,0.001025083,0.0006948516,0.0007872839,0.0005724211,0.0005447904],"domain_scores_gemma":[0.9984269,0.000262633,0.0000977997,0.0004645108,0.0003101671,0.0004380508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03788735,0.000682583,0.1342116,0.000694574,0.0002238655,0.00006021674,0.0004932964,0.001562314,0.7813821,0.00009510461,0.000508916,0.04219807],"study_design_scores_gemma":[0.02913546,0.05584024,0.05537131,0.0009612122,0.0001359835,0.00004940305,0.002035584,0.2851691,0.5585431,0.003410322,0.006684728,0.00266359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861212,0.01226534,0.00001979387,0.0006701423,0.00002715602,0.0006583326,0.00006258535,0.00001182975,0.0001635784],"genre_scores_gemma":[0.9919669,0.007214109,0.0001474998,0.00008919773,0.0003109281,0.00008735211,0.00005474702,0.00004802407,0.00008122413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2836068,"threshold_uncertainty_score":0.7095601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1861770248592693,"score_gpt":0.4505054595599348,"score_spread":0.2643284347006655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}