{"id":"W3118232987","doi":"10.1172/jci.insight.146175","title":"Blood donor exposome and impact of common drugs on red blood cell metabolism","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; Anschutz Medical Campus, University of Colorado; Boettcher Foundation","keywords":"Exposome; Medicine; Pharmacology; Drug; Metabolome; Red blood cell; Bioinformatics; Biology; Internal medicine; Pathology; Metabolite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004211077,0.0001672254,0.0004974226,0.00008218996,0.00003793983,0.00000630187,0.00005608429,0.0001210459,0.0003346737],"category_scores_gemma":[0.00003640451,0.000121026,0.0001522903,0.0001828004,0.00006165548,0.00004695841,0.00004039357,0.0002300736,0.00003965362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007664223,"about_ca_system_score_gemma":0.00005246912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003994282,"about_ca_topic_score_gemma":0.000001375941,"domain_scores_codex":[0.9991206,0.00006644897,0.000256049,0.000252888,0.0001398588,0.0001641757],"domain_scores_gemma":[0.9992951,0.00007228943,0.0001119362,0.0002424646,0.00005263817,0.0002255354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001373667,0.001156937,0.004470728,0.0002199971,0.0003229704,0.0000916048,0.003668332,0.000009205483,0.983155,0.0002636367,0.00456449,0.0007034321],"study_design_scores_gemma":[0.02111743,0.01343326,0.1585356,0.0001375983,0.00167855,0.0001024229,0.0003622151,0.0001793781,0.7644927,0.0002025166,0.03920805,0.0005503216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838623,0.0009262847,0.000002028891,0.000939536,0.0001348718,0.0002214286,0.0000188362,0.00005313444,0.01384163],"genre_scores_gemma":[0.9965867,0.0003635068,0.0001433556,0.002153019,0.0003384079,0.00000699986,0.00003420073,0.00002215242,0.0003516736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2186623,"threshold_uncertainty_score":0.4935296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197498822063385,"score_gpt":0.2551610218751894,"score_spread":0.2354111396688509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}