{"id":"W3118232987","doi":"10.1172/jci.insight.146175","title":"Blood donor exposome and impact of common drugs on red blood cell metabolism","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; Anschutz Medical Campus, University of Colorado; Boettcher Foundation","keywords":"Exposome; Medicine; Pharmacology; Drug; Metabolome; Red blood cell; Bioinformatics; Biology; Internal medicine; Pathology; Metabolite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000369036,0.0002753712,0.0004331487,0.0003432283,0.000123719,0.0005251389,0.0002226088,0.0002221508,0.001495049],"category_scores_gemma":[0.000816314,0.0001166964,0.0007728357,0.0004292725,0.00009956374,0.0002165934,0.0002453917,0.0002531636,0.0002287508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090297,"about_ca_system_score_gemma":0.0004371858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004510375,"about_ca_topic_score_gemma":0.004072819,"domain_scores_codex":[0.999843,0.00004995804,0.00001109857,0.00005663218,0.00002613315,0.00001314484],"domain_scores_gemma":[0.9997057,0.0001600914,0.00006452805,0.00003279101,0.000026253,0.00001064935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002510742,0.0005212853,0.5548485,0.0008249017,0.00204531,0.0006256909,0.0001632539,0.2636549,0.0700769,0.002715217,0.002747744,0.09926568],"study_design_scores_gemma":[0.0000835489,0.0008238906,0.2936742,0.00005147833,0.001023538,0.0005499212,0.0001497724,0.6466166,0.0454849,0.004034282,0.007436934,0.00007092231],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751915,0.001402318,0.01564822,0.000238444,0.00001867262,0.0000243812,0.005814208,0.0001825522,0.001479634],"genre_scores_gemma":[0.9874939,0.0009120278,0.006893327,0.0001063995,0.000009503334,0.00002531005,0.004014216,0.00001803134,0.000527156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004510375,"threshold_uncertainty_score":0.008968234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197498822063385,"score_gpt":0.2551610218751894,"score_spread":0.2354111396688509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}