{"id":"W3118259936","doi":"10.1186/s13195-020-00713-3","title":"Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; Biogen; BioClinica; Alzheimer Nederland; Eisai; ZonMw; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Cohort; Disease; Biomarker; Tau pathology; Internal medicine; Cognitive decline; Alzheimer's disease; Psychology; Medicine; Cohort study; Cognitive impairment; Oncology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004352361,0.0008060544,0.0007414105,0.001648003,0.0009194927,0.001378208,0.0008291699,0.001014585,0.0007519008],"category_scores_gemma":[0.009226965,0.0004431824,0.001217193,0.0009714253,0.0007309539,0.0006057558,0.001826653,0.0008143038,0.0001932493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006281429,"about_ca_system_score_gemma":0.0007027033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009267418,"about_ca_topic_score_gemma":0.007901552,"domain_scores_codex":[0.997686,0.0007276135,0.0001989945,0.0008251244,0.0002782759,0.0002839997],"domain_scores_gemma":[0.996472,0.0008880325,0.0008856074,0.0008293267,0.0004726094,0.0004524073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002407566,0.00007255883,0.9927554,0.00001494514,0.0003817721,0.0001332831,0.0006015369,0.0001721438,0.001093255,0.00009783515,0.0001957221,0.002074021],"study_design_scores_gemma":[0.0001347152,0.000237061,0.9972837,0.000009524158,0.000246759,0.0002477606,0.0003892874,0.0007237859,0.0002342085,0.0002415424,0.000228795,0.00002293767],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992175,0.00008395192,0.0002407536,0.00001827899,0.000005320736,0.00002338696,0.0002808145,0.000006319935,0.0001235296],"genre_scores_gemma":[0.9986381,0.00002936469,0.000257562,0.00001819359,0.000005702766,0.00003497898,0.0009240257,0.000005350559,0.0000868043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009267418,"threshold_uncertainty_score":0.02301776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2254002792862931,"score_gpt":0.4307753038321787,"score_spread":0.2053750245458855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}