{"id":"W3118270376","doi":"10.1186/s40709-020-00132-3","title":"The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co‐exposure with chemical inducers in culture","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Research - Thessaloniki","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hellenic Foundation for Research and Innovation; University of Toronto; General Secretariat for Research and Technology","keywords":"Epigenetics; Biology; Cellular differentiation; Chromatin; Cell biology; Methyltransferase; Cyclin-dependent kinase 6; Histone methyltransferase; Cell cycle; Erythropoiesis; Histone; Cell culture; Cell; Genetics; Cyclin-dependent kinase; Methylation; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003112293,0.00024548,0.0006645445,0.0002148687,0.0001668165,0.00006305943,0.0003485577,0.0006065157,0.00008116149],"category_scores_gemma":[0.00127151,0.0001114065,0.0001896431,0.0009783158,0.0006040816,0.0001204967,0.00008658626,0.003406936,0.000009289531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005484452,"about_ca_system_score_gemma":0.0009045447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002799934,"about_ca_topic_score_gemma":0.00004289646,"domain_scores_codex":[0.9959772,0.001022699,0.000802307,0.0003756475,0.001066869,0.0007553004],"domain_scores_gemma":[0.9978095,0.0008950238,0.0001607277,0.0002867158,0.0004996736,0.0003483004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003619556,0.0006604968,0.002550506,0.0000548676,0.00005357727,0.002214057,0.0008536887,0.00002016167,0.9837833,0.00004832272,0.001763092,0.004378393],"study_design_scores_gemma":[0.004645256,0.00229168,0.002092491,0.001284245,0.00001927072,0.0003808122,0.005683883,0.0000154027,0.969249,0.0004798663,0.01366123,0.0001969135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983659,0.01072932,0.00001676586,0.004263893,0.0001184714,0.0003263242,0.000006591625,0.00001114349,0.0008684417],"genre_scores_gemma":[0.9872702,0.01168602,0.000459193,0.0001818693,0.0001698574,0.00001641707,0.00001057557,0.00001917324,0.0001866822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01453433,"threshold_uncertainty_score":0.9988922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03615464206999405,"score_gpt":0.3546162446861734,"score_spread":0.3184616026161794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}