{"id":"W3118270471","doi":"10.1016/j.sbi.2020.11.005","title":"An integrated view of p53 dynamics, function, and reactivation","year":2021,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of Toronto","keywords":"DNA damage; Suppressor; Cell cycle checkpoint; P53 protein; Biology; Function (biology); Apoptosis; Senescence; Proteolysis; Cell biology; Computational biology; Cell cycle; DNA repair; Cancer research; DNA; Genetics; Cancer; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005423467,0.001007244,0.00130215,0.001613964,0.0002372405,0.0009764754,0.001012712,0.001498331,0.001340889],"category_scores_gemma":[0.0004306334,0.0004165803,0.000381251,0.00155477,0.0008079904,0.00216813,0.0006697486,0.002405956,0.002151569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008226043,"about_ca_system_score_gemma":0.0009461945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000837872,"about_ca_topic_score_gemma":0.0009696138,"domain_scores_codex":[0.9998516,0.00002735452,0.0000146379,0.00002888908,0.00006204992,0.00001543708],"domain_scores_gemma":[0.9998254,0.00007810193,0.00002139605,0.000007685291,0.00005091338,0.00001648332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001162636,0.00008686803,0.0001472528,0.02324198,0.0001216596,0.0003353572,0.0001227294,0.002633812,0.01335846,0.04730588,0.04386097,0.8686689],"study_design_scores_gemma":[0.00001018773,0.00008011374,0.0003235624,0.001833418,0.00006159363,0.0008735519,0.00003386275,0.0004435004,0.001588521,0.009357011,0.9853691,0.00002560648],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001720576,0.9967282,0.0007896186,0.0004588501,0.0002021311,0.000003450654,0.00001910268,0.00001303235,0.001613657],"genre_scores_gemma":[0.0007268072,0.9979673,0.0004575386,0.0002085869,0.0001314415,0.000005381234,0.00002998493,0.00000303694,0.00046994],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001613964,"threshold_uncertainty_score":0.005968451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04145178408375463,"score_gpt":0.3725988116106551,"score_spread":0.3311470275269005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}