{"id":"W3118288262","doi":"10.1038/s41398-020-01148-y","title":"Exemplar scoring identifies genetically separable phenotypes of lithium responsive bipolar disorder","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; University of Toronto; Montreal Neurological Institute and Hospital; Dalhousie University","funders":"Genome Atlantic; Killam Trusts; Dalhousie University; Bundesministerium für Bildung und Forschung; Nova Scotia Health Research Foundation; Canadian Institutes of Health Research; Genome Canada; Canada Research Chairs; Government of Canada; Dalhousie Medical Research Foundation","keywords":"Bipolar disorder; Schizophrenia (object-oriented programming); Phenotype; Receiver operating characteristic; Psychology; Major depressive disorder; Medicine; Mood; Clinical trial; Clinical psychology; Psychiatry; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009663681,0.0001485655,0.0002507002,0.00009155787,0.00009356171,0.0000138075,0.00005589606,0.0000930438,0.0006073865],"category_scores_gemma":[0.00002011673,0.0001406309,0.0001750594,0.0002663781,0.00007423747,0.00007439726,0.00001192631,0.0001424982,0.00004656508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009767962,"about_ca_system_score_gemma":0.0004036011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003422568,"about_ca_topic_score_gemma":0.0002559327,"domain_scores_codex":[0.9987926,0.00005326587,0.0003258091,0.0002830528,0.0003547683,0.0001905447],"domain_scores_gemma":[0.999332,0.00006746982,0.00005117491,0.0002667307,0.0001941545,0.00008843327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00056267,0.0009959731,0.9662547,0.0003507168,0.0005354326,0.000008612101,0.0005304204,0.0001726942,0.009801197,0.01618141,0.0003081859,0.004298042],"study_design_scores_gemma":[0.002472154,0.0001713926,0.9526954,0.0001806403,0.0004343036,0.00006499398,0.0002069468,0.0001126218,0.006164111,0.01329494,0.02399513,0.0002073291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7819135,0.1964156,0.004146094,0.00827081,0.0007420601,0.0003828458,0.0001201843,0.00007181413,0.007937105],"genre_scores_gemma":[0.9781765,0.0005414657,0.01918317,0.0001883225,0.0001659441,0.00001558304,0.0001845943,0.00003471875,0.001509648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1962631,"threshold_uncertainty_score":0.6650456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429847645123631,"score_gpt":0.2813142294593218,"score_spread":0.2670157530080855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}