{"id":"W3118300061","doi":"10.1038/s42003-020-01557-1","title":"Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Children's Hospital; McGill University Health Centre; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"International Progressive MS Alliance","keywords":"Autophagy; Link (geometry); Cell biology; Oligodendrocyte; Neuroscience; Biology; Medicine; Apoptosis; Central nervous system; Genetics; Computer science; Myelin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165253,0.0001383596,0.0002617639,0.0003021353,0.0003438463,0.00003809915,0.0006764497,0.00009529041,0.00004866352],"category_scores_gemma":[0.001814507,0.000141255,0.00004772055,0.0007388041,0.0001928012,0.00007351076,0.0007937332,0.000185986,0.00008539087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001130936,"about_ca_system_score_gemma":0.00007574566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006350522,"about_ca_topic_score_gemma":0.00003460833,"domain_scores_codex":[0.9977897,0.001063545,0.0004973792,0.0003836789,0.00008441155,0.0001812579],"domain_scores_gemma":[0.9976057,0.0005158298,0.0001297865,0.001483353,0.0001314167,0.000133942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000163168,0.0000425293,0.00001752431,0.000002959002,0.000003072949,0.000003361278,0.0003439933,0.000004840068,0.7708617,0.2252093,0.00005297995,0.003441438],"study_design_scores_gemma":[0.0002200474,0.0001982273,0.001034815,0.00001089921,0.000009024017,0.00002611324,0.00002999952,0.0001007403,0.9712524,0.003331004,0.02365898,0.0001277799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909618,0.0004513447,0.0002352651,0.006440108,0.0001518073,0.0003235313,0.0001120328,0.0001383183,0.001185779],"genre_scores_gemma":[0.9925515,0.0009442968,0.002814337,0.002851293,0.00001870763,0.00006857812,0.00003519996,0.00001807825,0.0006980023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2218783,"threshold_uncertainty_score":0.5760213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0876690707014694,"score_gpt":0.3473484809981172,"score_spread":0.2596794102966478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}