{"id":"W3118317576","doi":"10.1002/stem.3331","title":"IGFBPs mediate IGF-1's functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; Medical Research Council Canada; National Centre for the Replacement, Refinement and Reduction of Animals in Research; H2020 European Research Council; Retina UK","keywords":"Biology; Retinal; Cell biology; Cellular differentiation; Retina; Stem cell; Retinal regeneration; Organoid; Induced pluripotent stem cell; Neuroscience; Genetics; Regeneration (biology); Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001649774,0.0001888595,0.0001522599,0.00009360213,0.0001215017,0.00005044831,0.00008497733,0.0001193277,0.00006936439],"category_scores_gemma":[0.000007928866,0.0001973414,0.00003799309,0.0001867547,0.00002142392,0.000008471809,0.0001424178,0.00009077819,0.00004285538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007477275,"about_ca_system_score_gemma":0.000145294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004467725,"about_ca_topic_score_gemma":0.0001029248,"domain_scores_codex":[0.9986398,0.00008146911,0.0003226414,0.0004659048,0.0002147565,0.0002754458],"domain_scores_gemma":[0.9995164,0.00001162523,0.00008477746,0.000156515,0.0001143064,0.0001163278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111271,0.00007934465,0.01860478,0.0001060606,0.00001671021,0.000009540026,0.0007265974,0.00002360097,0.9774071,0.00000458377,0.000321621,0.002588806],"study_design_scores_gemma":[0.0006787186,0.00007109068,0.08016869,0.00004614779,0.00001102545,0.000005505995,0.001039283,0.00001437871,0.9110707,0.000003181739,0.006637373,0.0002538892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974667,0.0003204099,0.0006449938,0.0001173187,0.0003076492,0.0002390075,0.000007808347,0.00001444814,0.0008816823],"genre_scores_gemma":[0.9901805,0.0001477861,0.0006016149,0.00005511861,0.00006658459,0.00004707085,0.0001643388,0.00002282708,0.008714177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06633636,"threshold_uncertainty_score":0.8047348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004861253997840489,"score_gpt":0.1854620113226038,"score_spread":0.1806007573247633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}