{"id":"W3118317576","doi":"10.1002/stem.3331","title":"IGFBPs mediate IGF-1's functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; Medical Research Council Canada; National Centre for the Replacement, Refinement and Reduction of Animals in Research; H2020 European Research Council; Retina UK","keywords":"Biology; Retinal; Cell biology; Cellular differentiation; Retina; Stem cell; Retinal regeneration; Organoid; Induced pluripotent stem cell; Neuroscience; Genetics; Regeneration (biology); Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139137,0.0003959923,0.0002432428,0.0002306861,0.0001643086,0.000353957,0.0001953203,0.0002200249,0.001191796],"category_scores_gemma":[0.0001325648,0.0001519091,0.000277519,0.000146399,0.0002035741,0.0002362957,0.0002756952,0.000503861,0.0005276333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565319,"about_ca_system_score_gemma":0.0003014038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001768231,"about_ca_topic_score_gemma":0.002461668,"domain_scores_codex":[0.9998584,0.00001780283,0.00001958168,0.00002963416,0.00004903238,0.00002561284],"domain_scores_gemma":[0.9999121,0.00001536055,0.00002064236,0.00001133437,0.0000190171,0.00002143355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004620537,0.000004521755,0.000181437,0.00003955722,0.000002134969,0.00003738401,0.00002730897,0.00004204256,0.9983171,0.00007761883,0.00002445632,0.001200176],"study_design_scores_gemma":[0.000006610213,0.00006740481,0.005710391,0.00001024112,0.00001749913,0.00013556,0.00004262385,0.0004133478,0.9891215,0.00004064424,0.004428791,0.000005407255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692712,0.009108219,0.01373934,0.0001627619,0.00009998844,0.00009621418,0.001440678,0.0001892514,0.005892423],"genre_scores_gemma":[0.9819794,0.002518899,0.007338623,0.00007605128,0.00001289288,0.00007125713,0.001400866,0.0000319428,0.006569995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768231,"threshold_uncertainty_score":0.003986955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004861253997840489,"score_gpt":0.1854620113226038,"score_spread":0.1806007573247633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}