{"id":"W3118320693","doi":"10.1242/jcs.247809","title":"Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair","year":2021,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; Karolinska Institutet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancerfonden; University of Oxford","keywords":"Biology; SUMO protein; DNA repair; DNA damage; Cell biology; DNA; Poly ADP ribose polymerase; PARP1; DNA ligase; RNF4; Polymerase; Molecular biology; Ubiquitin; Genetics; Zinc finger; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013399,0.0001543058,0.000225227,0.0001003118,0.0001286525,0.0001038909,0.0004248368,0.00008391344,0.00004406119],"category_scores_gemma":[0.000123311,0.0001319964,0.0001708986,0.0002602183,0.00009916423,0.00002789596,0.0001111815,0.0001129891,0.00001146733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000660991,"about_ca_system_score_gemma":0.0008074188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001307869,"about_ca_topic_score_gemma":0.00004114594,"domain_scores_codex":[0.9980666,0.00006681915,0.0004837857,0.0003805772,0.0006824189,0.000319785],"domain_scores_gemma":[0.998251,0.00001588833,0.0003404938,0.0003728629,0.0007095897,0.0003101787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002276228,0.0001245719,0.0002751442,0.00001126687,0.0000216762,0.00005910917,0.00006773767,0.00009146261,0.9974824,0.0001016279,0.000685299,0.000852086],"study_design_scores_gemma":[0.001711905,0.0005701977,0.0008257867,0.00003025443,0.00003031366,0.0002540387,0.0001148785,0.00005381846,0.9783305,0.00006391851,0.01785569,0.0001587241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872568,0.0009965968,0.006198954,0.0009645972,0.0007727247,0.0003439063,0.00001371683,0.00001431658,0.003438384],"genre_scores_gemma":[0.9925073,0.00008423906,0.004330191,0.000543779,0.0002351978,0.000008341121,0.000005422168,0.00001216213,0.002273389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01915192,"threshold_uncertainty_score":0.5382657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164126212224734,"score_gpt":0.2789253191591139,"score_spread":0.2572840570368666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}