{"id":"W3118332071","doi":"10.1093/nar/gkaa1232","title":"SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation; Government of Alberta; Natural Sciences and Engineering Research Council of Canada; Alberta Health Services","keywords":"Biology; SUMO protein; Homologous recombination; Genome instability; DNA damage; RAD51; Non-homologous end joining; Cell biology; DNA replication; DNA repair; Ubiquitin ligase; Replication protein A; Ubiquitin; Molecular biology; Genetics; DNA; DNA-binding protein; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127469,0.0003790861,0.0002638766,0.0001179674,0.0002660164,0.0003824297,0.0002402554,0.0002833888,0.001580666],"category_scores_gemma":[0.0001329208,0.0001427203,0.0003360568,0.0001287316,0.0002745533,0.0003501204,0.0003132456,0.0004183763,0.000806344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003433664,"about_ca_system_score_gemma":0.0002611121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004939698,"about_ca_topic_score_gemma":0.0004859222,"domain_scores_codex":[0.9999036,0.000009734854,0.000007992382,0.00003269026,0.00002120908,0.00002481746],"domain_scores_gemma":[0.9998858,0.00001054386,0.0000339006,0.00001810876,0.00001365326,0.0000380181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008912582,0.00001021621,0.0004198783,0.00001968333,0.000003515128,0.00006419473,0.000006776498,0.00007731778,0.9981954,0.0001225431,0.00001628701,0.0009751669],"study_design_scores_gemma":[0.000007772139,0.00006201813,0.006950937,0.000004245569,0.000007253701,0.0003276391,0.00001895675,0.0009538007,0.9904406,0.00009631544,0.001126798,0.000003604419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919761,0.00164634,0.004553701,0.00009524276,0.0000158269,0.00001250688,0.0002073838,0.00003863047,0.001454225],"genre_scores_gemma":[0.9961907,0.000602597,0.001402519,0.00001634458,0.000004516739,0.000006724622,0.0003062995,0.00001188188,0.001458375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580666,"threshold_uncertainty_score":0.005287826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05264261467447912,"score_gpt":0.321319919075758,"score_spread":0.2686773044012789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}