{"id":"W3118334358","doi":"10.1002/art.41651","title":"Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging‐Induced Osteoarthritis in Mice","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Osteoarthritis; Pannexin; Synovitis; Medicine; Cartilage; Degeneration (medical); Mediator; Appendicular skeleton; Context (archaeology); Pathology; Synovial joint; Physiology; Endocrinology; Internal medicine; Arthritis; Anatomy; Articular cartilage; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003339878,0.0009168315,0.0004999574,0.001042289,0.0002400223,0.0003573668,0.0003905769,0.0007258388,0.002372589],"category_scores_gemma":[0.0001282353,0.0003902949,0.000711002,0.000357351,0.0004832024,0.0003877647,0.0003953226,0.0008644513,0.0005430968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003621291,"about_ca_system_score_gemma":0.0003104634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00058537,"about_ca_topic_score_gemma":0.001132297,"domain_scores_codex":[0.9996438,0.00003215162,0.00005967744,0.0001124523,0.00007905254,0.00007281827],"domain_scores_gemma":[0.9995845,0.00002396528,0.0002126468,0.00002560929,0.00002310991,0.0001301028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001991242,0.00004531627,0.0002313888,0.00003451987,0.000009984184,0.00008906084,0.00001468774,0.000040914,0.9987592,0.00004717295,0.00002897949,0.0004997418],"study_design_scores_gemma":[0.0002470544,0.002047159,0.02860703,0.00005610591,0.0001358081,0.002017798,0.0001047262,0.001350217,0.9612116,0.0001334647,0.004062622,0.00002647623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903303,0.001773522,0.004463365,0.0001368885,0.00006472854,0.0001112313,0.00169999,0.0003505358,0.001069409],"genre_scores_gemma":[0.9790947,0.002102399,0.008206905,0.0002149056,0.00003908063,0.0002774206,0.002379785,0.0001568425,0.007527851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372589,"threshold_uncertainty_score":0.007937133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496789171397342,"score_gpt":0.2608041790193091,"score_spread":0.2458362873053357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}