{"id":"W3118356453","doi":"10.1101/2021.01.14.426475","title":"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fast Grants; University of Washington; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Epitope; Virology; Monoclonal antibody; Glycoprotein; Antigen; Biology; Antibody; Effector; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Neutralization; Epitope mapping; Coronavirus disease 2019 (COVID-19); Cell biology; Molecular biology; Genetics; Virus; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002560625,0.0007671963,0.001777873,0.0006202977,0.0001904053,0.0001797501,0.0006027016,0.0009009902,0.00001349314],"category_scores_gemma":[0.001155346,0.0008098898,0.0007929037,0.0008565169,0.0003413661,0.0001562937,0.0007966525,0.001314677,0.00002774359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005708031,"about_ca_system_score_gemma":0.002576414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611513,"about_ca_topic_score_gemma":0.00001149419,"domain_scores_codex":[0.9945928,0.0003440208,0.001320989,0.001751999,0.0009320804,0.001058089],"domain_scores_gemma":[0.994693,0.00030855,0.0006543543,0.00260625,0.001596895,0.0001409184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003212432,0.0004376097,0.05192857,0.005199727,0.0003952858,0.0003394847,0.00006784432,4.747392e-7,0.9410096,0.00006904678,0.0002224384,0.000008702733],"study_design_scores_gemma":[0.001834737,0.0001907116,0.06695214,0.001880578,0.0001898857,3.886059e-7,0.0000192037,0.0001867747,0.9153173,0.00001303535,0.01271638,0.00069886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894552,0.002172638,0.004340049,0.0002203538,0.0006273257,0.002573609,0.0003541303,0.000234182,0.00002251158],"genre_scores_gemma":[0.9792774,0.00003991984,0.01443825,0.004831593,0.0006509341,0.0005764674,0.000001257737,0.0001818591,0.000002296981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02569227,"threshold_uncertainty_score":0.9994352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04800187617893253,"score_gpt":0.3219942797676448,"score_spread":0.2739924035887122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}